From the Guidelines
Monjaro (tirzepatide) primarily causes fat loss, with some potential for muscle loss, but this can be minimized with regular strength training exercises and adequate protein intake. When considering the effects of Monjaro on body composition, it's essential to prioritize strategies that minimize muscle loss while maximizing fat loss, as muscle mass is crucial for overall health and mobility. The medication works by mimicking two hormones (GLP-1 and GIP) that regulate blood sugar and appetite, leading to a calorie deficit that primarily burns fat for energy 1. To preserve lean muscle mass while using Monjaro, incorporating regular strength training exercises (2-3 sessions/week) and ensuring adequate protein intake (approximately 1.2-2.0 grams per kilogram of body weight daily) is recommended 1. Additionally, reducing sedentary time and breaking up periods of inactivity with light physical activities can also support overall health and weight management 1. While the provided evidence does not directly mention Monjaro, the principles of weight management and the importance of preserving muscle mass during weight loss are well-established, and the use of GLP-1 receptor agonists (like liraglutide) provides a relevant context for understanding how such medications can affect body composition 1. Therefore, the focus should be on a holistic approach to weight management that includes medication, diet, exercise, and lifestyle changes to achieve the best outcomes in terms of morbidity, mortality, and quality of life.
From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
Monjaro and Weight Loss
- Monjaro, also known as Tirzepatide, is a dual glucose-dependent insulinotropic polypeptide (GIP) receptor and GLP-1 receptor agonist used for the management of type 2 diabetes mellitus (T2DM) 2.
- It has been shown to have potent glucose-lowering and weight-loss effects, with adverse effects comparable to GLP-1 receptor agonists 2.
Effect on Muscle and Fat Loss
- There is no direct evidence from the provided studies on the effect of Monjaro on muscle loss or fat loss.
- However, studies on protein supplementation and resistance training in older adults suggest that combining these interventions can improve muscle mass and strength 3, 4, 5, 6.
- It is unclear whether Monjaro would have a similar effect, as its primary mechanism is related to glucose control and weight loss, rather than muscle growth or strength 2.
Related Research
- Research on protein supplementation and resistance training in older adults has shown that this combination can improve muscle mass, strength, and physical function 3, 4, 5, 6.
- These studies suggest that resistance training, with or without protein supplementation, can be an effective way to improve muscle mass and strength in older adults 3, 4, 5, 6.
- However, the effect of Monjaro on muscle loss or fat loss is not directly addressed in these studies, and more research would be needed to determine its specific effects 2.