What are the guidelines for using lidocaine viscous (lidocaine) in adults and pediatric patients for oral pain management, especially in those with a history of allergies or certain medical conditions like heart problems?

Lidocaine Viscous for Oral Pain Management

Lidocaine viscous should be applied to affected oral areas not more than 3 to 4 times daily in adults and children over 12 years, with hands washed thoroughly after application; it is contraindicated in patients with known allergy to amide anesthetics, and should be avoided in those with cardiac disease, hepatic dysfunction, or seizure disorders. 1, 2

Dosing and Administration

Adults and Pediatric Patients Over 12 Years

• Apply to affected oral area no more than 3 to 4 times daily 1
• After application, wash hands thoroughly with soap and water to prevent inadvertent transfer to mucous membranes or eyes 1
• Avoid mucous membrane contact or ingestion beyond the intended treatment area 2

Children Under 12 Years

• Consult a physician before use 1
• The topical anesthetic dose should be lower for patients <12 months old or weighing <10 kg 2
• Maximum doses for infiltrative lidocaine in children are 1.5-2.0 mg/kg without epinephrine and 3.0-4.5 mg/kg with epinephrine 2

Contraindications and Precautions

Absolute Contraindications

• Allergy to amide anesthetics is the primary contraindication 2
• True allergy to lidocaine is uncommon (representing only 1% of adverse reactions), but when present, requires alternative anesthetic selection 2, 3
• Non-intact skin or mucous membranes 2

Relative Contraindications Requiring Careful Consideration

• Cardiac disease: Lidocaine can cause bradycardia, sinus arrest, and hypotension as toxic effects 2
• Hepatic disease or dysfunction: Lidocaine is eliminated almost exclusively by the liver, with half-life increasing from 1-2 hours in normal subjects to >4 hours in patients with complications 2
• Seizure disorders: Lidocaine toxicity includes muscle twitching and seizures 2
• Renal dysfunction: Increases risk of toxicity, particularly in patients with poor cardiac output 2
• Patients >70 years of age: Higher risk of developing lidocaine toxicity 2
• Congestive heart failure or cardiogenic shock: Dramatically prolongs lidocaine half-life to >20 hours 2
• Preexisting neurologic dysfunction: Increases susceptibility to CNS toxicity 2

Managing Patients with Allergy History

For Suspected Lidocaine Allergy

• Use ester-type local anesthetics as an alternative, since cross-reaction between amide and ester types is rare 2
• Consider 1% diphenhydramine injection, though it has longer onset (5 minutes vs. 1 minute for lidocaine) and limited efficacy 2
• Bacteriostatic saline (0.9% benzyl alcohol in normal saline) is another alternative for small procedures 2
• Perform intradermal testing to confirm true allergy versus other adverse reactions (psychomotor, autonomic, or toxic) 3, 4, 5

Testing Protocol

• Patch testing and intradermal testing can identify delayed hypersensitivity 3, 4, 5
• Skin prick tests identify immediate reactions 5
• Intradermal testing with lidocaine 1%, mepivacaine 2%, and bupivacaine 0.5% can guide alternative selection 3
• Bupivacaine frequently yields negative results even when lidocaine is positive 3

Recognition of Toxicity

Central Nervous System Symptoms (Early Warning Signs)

• Perioral numbness and tingling of lips or tongue 2
• Facial tingling and metallic taste 2
• Dizziness, light-headedness, and tinnitus 2
• Drowsiness, confusion, and slurred speech 2
• Muscle twitching and tremor 2

Severe Toxicity

• Seizures and altered consciousness 2
• Respiratory depression or arrest 2
• Myocardial and circulatory depression 2
• Bradycardia, sinus arrest, and hypotension 2
• Coma, ventricular arrest, and death at highest concentrations 2

Special Populations

Cardiac Patients

• Lidocaine does not significantly affect AV nodal conduction or sinus node automaticity at therapeutic doses 6
• Absolutely contraindicated in Wolff-Parkinson-White syndrome with atrial fibrillation, as it can facilitate antegrade conduction along the accessory pathway, resulting in ventricular rate acceleration, hypotension, or ventricular fibrillation 6
• Bradycardia and asystole represent toxic effects, not therapeutic actions, particularly in acute myocardial infarction patients 2, 6
• Reduce infusion rates in patients with cardiac failure, as elimination half-life increases dramatically 2

Hepatic Dysfunction

• Avoid acetaminophen in patients with hepatic disease 2
• Lidocaine elimination is almost exclusively hepatic, requiring dose reduction 2
• Monitor serum levels with prolonged use 2

Common Pitfalls to Avoid

• Do not exceed recommended frequency: Maximum 3-4 applications daily 1
• Avoid combining with other local anesthetics: Do not use within 4 hours of nerve blocks, fascial plane blocks, or infiltration 2
• Do not apply to broken or inflamed skin: Only intact skin is appropriate 2, 7
• Avoid excessive heat application: May increase systemic absorption 7
• Do not confuse adverse reactions with true allergy: Most reactions are psychomotor, autonomic, or toxic rather than immunologic 8, 5