What is the recommended dose of Ofloxacin (Fluoroquinolone antibiotic)?

From the Guidelines

The recommended dose of Ofloxacin is 400 mg every 12 hours orally.

Dosage Information

• For adults, the dose is 400 mg every 12 hours orally 1.
• For children, the dose is 7.5 mg/kg every 12 hours orally, with a maximum dose of 400 mg/dose 1.

Clinical Use

Ofloxacin is used to treat various infections, including uncomplicated urogenital and anorectal infections caused by N. gonorrhoeae, with a cure rate of 98.6% in clinical trials 1.

Important Considerations

• Ofloxacin is no longer universally effective against N. gonorrhoeae in the United States, similar to ciprofloxacin 1.
• Levofloxacin, the active l-isomer of ofloxacin, can be used as a single dose of 250 mg in place of ofloxacin 1.

From the FDA Drug Label

The usual dose of ofloxacin tablets is 200 mg to 400 mg orally every 12 h as described in the following dosing chart. Infection*Unit DoseFrequencyDurationDaily Dose

• DUE TO THE DESIGNATED PATHOGENS (see INDICATIONS AND USAGE). Acute Bacterial Exacerbation of Chronic Bronchitis400 mgq12h10 days800 mg Comm Acquired Pneumonia400 mgq12h10 days800 mg Uncomplicated Skin and Skin Structure Infections400 mgq12h10 days800 mg Acute, Uncomplicated Urethral and Cervical Gonorrhea400 mgsingle dose1 day400 mg Nongonococcal Cervicitis/Urethritis due to C. trachomatis300 mgq12h7 days600 mg Mixed Infection of the Urethra and Cervix due to C. trachomatis and N gonorrhoeae300 mgq12h7 days600 mg Acute Pelvic Inflammatory Disease400 mgq12h10 to 14 days800 mg Uncomplicated Cystitis due to E. coli or K. pneumoniae200 mgq12h3 days400 mg Uncomplicated Cystitis due to Other Approved Pathogens200 mgq12h7 days400 mg Complicated UTI's200 mgq12h10 days400 mg Prostatitis due to E coli300 mgq12h6 weeks600 mg

The recommended dose of Ofloxacin is 200 mg to 400 mg orally every 12 hours. The specific dose and duration of treatment depend on the type of infection being treated, as outlined in the dosing chart 2.

• Key Infections and Doses:
  • Acute Bacterial Exacerbation of Chronic Bronchitis: 400 mg every 12 hours for 10 days
  • Community Acquired Pneumonia: 400 mg every 12 hours for 10 days
  • Uncomplicated Skin and Skin Structure Infections: 400 mg every 12 hours for 10 days
  • Acute, Uncomplicated Urethral and Cervical Gonorrhea: 400 mg single dose
  • Nongonococcal Cervicitis/Urethritis due to C. trachomatis: 300 mg every 12 hours for 7 days
  • Mixed Infection of the Urethra and Cervix: 300 mg every 12 hours for 7 days
  • Acute Pelvic Inflammatory Disease: 400 mg every 12 hours for 10 to 14 days
  • Uncomplicated Cystitis: 200 mg every 12 hours for 3 or 7 days
  • Complicated UTI's: 200 mg every 12 hours for 10 days
  • Prostatitis due to E coli: 300 mg every 12 hours for 6 weeks

From the Research

Dosage Information

• The recommended dose of Ofloxacin is not explicitly stated in the provided studies, but the studies mention various dosages used in clinical trials, such as 300 mg, 400 mg, or 600 mg daily 3.
• The duration of treatment varied from 6 to 14 days in one study 3.
• Another study mentions that ofloxacin has a high oral bioavailability, with peak serum concentrations obtained one to two hours following oral dosing 4.
• The pharmacokinetics of ofloxacin are characterized by almost complete bioavailability (95 to 100%), peak serum concentrations in the range of 2 to 3 mg/L after a 400mg oral dose, and an average half-life of 5 to 8h 5.

Administration and Efficacy

• Ofloxacin can be administered orally or intravenously, with the oral formulation having near-complete bioavailability 6, 4.
• The efficacy of ofloxacin has been demonstrated in various infections, including urinary tract infections, respiratory tract infections, and skin and soft tissue infections 6, 4, 3.
• Ofloxacin has been shown to be effective against a wide range of bacterial pathogens, including Gram-positive and Gram-negative bacteria 6, 4, 3.

Safety and Tolerability

• The most commonly reported adverse events with ofloxacin are gastrointestinal, neurological, and dermatological 6.
• Ofloxacin has been associated with a lower incidence of photosensitivity and tendinitis, but a higher incidence of some neurological events compared to other fluoroquinolones 6.
• The safety profile of ofloxacin is generally considered good, but it should not be used in children or in pregnant or nursing women 4.