From the Guidelines
Nystatin tablets are not the primary recommended treatment for candidiasis, instead, nystatin suspension is recommended for mild disease, with a dosage of 100,000 U/mL, 4–6 mL, 4 times daily, for 7–14 days 1.
Key Points
- Nystatin suspension is an alternative for mild disease, with a dosage of 100,000 U/mL, 4–6 mL, 4 times daily, for 7–14 days 1.
- Nystatin pastilles can also be used, with a dosage of 1–2 pastilles (200,000 U each), 4 times daily, for 7–14 days 1.
- Clotrimazole troches and miconazole mucoadhesive buccal tablets are also recommended for mild disease 1.
- Fluconazole is recommended for moderate to severe disease, with a dosage of 100–200 mg daily, for 7–14 days 1.
Treatment Guidelines
The treatment guidelines for candidiasis recommend the use of nystatin suspension or pastilles for mild disease, and fluconazole for moderate to severe disease 1.
- Oropharyngeal candidiasis: nystatin suspension, clotrimazole troches, or miconazole mucoadhesive buccal tablets for mild disease, and fluconazole for moderate to severe disease 1.
- Esophageal candidiasis: fluconazole, itraconazole, or posaconazole for treatment 1.
From the FDA Drug Label
DESCRIPTION Nystatin is an antimycotic polyene antibiotic obtained from Streptomyces noursei. There is no information about Nystatin tablets in the provided drug labels, only information about Nystatin Oral Suspension.
- The drug labels provided do not mention tablets.
- The information provided is about Nystatin Oral Suspension. The FDA drug label does not answer the question.
From the Research
Nystatin Tablets: Overview
- Nystatin tablets are used to treat fungal infections in the mouth, specifically candidiasis 2, 3, 4, 5.
- They are not absorbed through the stomach and are only effective in treating fungal infections in the mouth 2.
Mechanism of Action and Formulation
- Nystatin buccoadhesive tablets release the drug slowly due to poor solubility in water and the presence of polymers with mucoadhesive properties 2.
- Solid dispersion formulations and the addition of surfactants can improve drug release from buccoadhesive tablets 2.
- Mucoadhesive tablets containing nystatin can remain attached to the buccal mucosa for several hours, releasing the drug and maintaining its concentration in saliva above the minimum inhibitory concentration (MIC) 5.
Clinical Use and Efficacy
- Nystatin tablets are effective in preventing systemic candidosis in patients at risk, particularly those with compromised immune systems 3.
- They are also used to treat oral candidosis, with mucoadhesive extended-release tablets showing promising results in vivo 5.
- The use of nystatin and chlorhexidine in oral medicine has been reviewed, highlighting their properties, indications, and pitfalls, particularly in geriatric patients 4.