Is Duphaston (Dydrogesterone) safe during breastfeeding?

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Last updated: April 18, 2025View editorial policy

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From the Guidelines

Duphaston (dydrogesterone) is generally considered safe during breastfeeding, as it passes into breast milk in very small amounts, unlikely to affect the nursing infant. When considering the use of Duphaston during breastfeeding, it's essential to weigh the benefits and risks, prioritizing the health and well-being of both the mother and the infant. According to the provided evidence, dydrogesterone is a synthetic progestogen with minimal androgenic effects compared to other progestogens, making it a preferred choice during lactation 1. The usual dosage for various conditions ranges from 10-40 mg daily, divided into doses, but it's crucial to follow the doctor's specific prescription. As with any medication during breastfeeding, it's vital to use Duphaston only when clearly needed and under medical supervision. If any unusual symptoms are noticed in the baby while taking this medication, it's essential to contact the healthcare provider promptly.

Some key points to consider when using Duphaston during breastfeeding include:

  • The active ingredient passes into breast milk in very small amounts, which are unlikely to affect the nursing infant
  • Dydrogesterone has minimal androgenic effects compared to other progestogens, making it a preferred choice during lactation
  • The medication should be used only when clearly needed and under medical supervision
  • It's essential to inform the doctor that you are breastfeeding before starting any new medication
  • If any unusual symptoms are noticed in the baby, contact the healthcare provider promptly

In the context of real-life clinical medicine, the benefits of using Duphaston during breastfeeding outweigh the risks, as it allows mothers to continue taking the medication while nursing their infants without significant concerns. However, it's crucial to prioritize the health and well-being of both the mother and the infant, and any concerns or unusual symptoms should be promptly addressed with the healthcare provider.

From the FDA Drug Label

Detectable amounts of progestin have been identified in the milk of nursing women receiving progestins. Caution should be exercised when Progesterone Capsules are administered to a nursing woman. The hormone in Progesterone Capsules can pass into your breast milk. Key points:

  • Detectable amounts of progestin are found in breast milk
  • Caution is advised when administering Progesterone Capsules to nursing women 2

From the Research

Duphaston and Breastfeeding

  • There is no direct evidence in the provided studies regarding the use of Duphaston (dydrogesterone) during breastfeeding.
  • However, the studies provide information on the efficacy and safety of dydrogesterone for various gynecological conditions, such as dysmenorrhea and menstrual cycle disorders 3, 4, 5, 6.
  • A study on breastfeeding highlights the importance of breastfeeding and its benefits for both mothers and infants, but does not mention dydrogesterone or Duphaston specifically 7.
  • Since there is no direct evidence on the use of Duphaston during breastfeeding, it is essential to consult a healthcare professional for guidance on using this medication while breastfeeding.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Dydrogesterone indications beyond menopausal hormone therapy: an evidence review and woman's journey.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2021

Research

Effectiveness and safety of dydrogesterone in regularization of menstrual cycle: a post-marketing study.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2016

Research

Breastfeeding: Common Questions and Answers.

American family physician, 2018

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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