Is Primolut-N (Norethisterone) safe during breastfeeding?

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From the FDA Drug Label

In general, no adverse effects have been found on breastfeeding performance or on the health, growth, or development of the infant. However, isolated post-marketing cases of decreased milk production have been reported. Small amounts of progestins pass into the breast milk of nursing mothers, resulting in detectable steroid levels in infant plasma.

Primolut Nor and Breastfeeding:

  • No adverse effects on breastfeeding performance or infant health have been found in general.
  • However, there have been isolated cases of decreased milk production.
  • Small amounts of progestins are passed into breast milk, resulting in detectable steroid levels in infant plasma. 1

From the Research

Primolut N (norethisterone) is generally not recommended during breastfeeding due to its potential to pass into breast milk and affect the baby, as well as reduce milk supply. Norethisterone is a progestogen that may pass small amounts of hormones to the infant, posing a risk to their health 2. Alternative contraceptive options that are safer during breastfeeding include progestogen-only pills like desogestrel (Cerazette), the progesterone-only implant, or non-hormonal methods such as copper IUDs.

Key Considerations

  • Norethisterone can reduce milk supply and may pass small amounts of hormones to the infant, posing a risk to their health 2.
  • Alternative contraceptive options are available and may be safer for breastfeeding women, such as progestogen-only pills or non-hormonal methods like copper IUDs.
  • If norethisterone must be taken, timing is crucial - taking it immediately after breastfeeding and waiting several hours before the next feeding can minimize the amount transferred to the baby.

Safer Alternatives

  • Progestogen-only pills like desogestrel (Cerazette) may be a safer alternative for breastfeeding women.
  • The progesterone-only implant is another option that may be safer during breastfeeding.
  • Non-hormonal methods, such as copper IUDs, are also available and do not pose the same risks as hormonal contraceptives.

Important Reminders

  • Always consult a healthcare provider before starting or stopping any medication during breastfeeding to ensure the best approach for both the mother and the baby.
  • A thorough evaluation of the patient's health and preferences is essential for effectively managing menstrual disorders or endometriosis while breastfeeding.

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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