Mabthera 1400mg Subcutaneous Room Temperature Stability
Diluted Mabthera (rituximab) solutions for infusion may be stored at room temperature for up to 24 hours, though refrigerated storage at 2°C to 8°C is preferred since the solution contains no preservative. 1
Storage Guidelines from FDA Label
Diluted rituximab solutions have been demonstrated stable for 24 hours at room temperature after the initial 24-hour refrigerated storage period 1
The preferred storage method is refrigeration at 2°C to 8°C (36°F to 46°F) for up to 24 hours after dilution, followed by the additional 24-hour room temperature stability window 1
Total stability window: 48 hours maximum (24 hours refrigerated + 24 hours at room temperature) 1
Critical Storage Requirements
Rituximab solutions lack preservatives, which is why refrigerated storage is strongly recommended over room temperature storage 1
The product should be a clear, colorless liquid - do not use if particulates or discoloration are present 1
Dilution must be performed using aseptic technique to a final concentration of 1-4 mg/mL in either 0.9% Sodium Chloride or 5% Dextrose Injection 1
Common Pitfalls to Avoid
Do not assume extended room temperature stability beyond 24 hours - the absence of preservatives limits microbial protection 1
Discard any unused portion left in the vial after withdrawal - do not attempt to store opened vials 1
Do not mix or dilute with other drugs in the infusion bag 1
No incompatibilities exist with polyvinylchloride or polyethylene bags, so standard IV bags are appropriate 1