What is another name for ramelteon?

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Brand Name for Ramelteon

Ramelteon is marketed under the brand name Rozerem 1, 2, 3.

Key Identifying Information

  • Rozerem is manufactured by Takeda Pharmaceutical Company Limited, Osaka, Japan 1
  • It is available as an 8 mg tablet formulation 2
  • The medication should be taken approximately 30 minutes prior to bedtime 2

Distinguishing Regulatory Features

  • Ramelteon/Rozerem is the first melatonin receptor agonist approved by the FDA for insomnia treatment 2, 4
  • It is notably NOT classified as a DEA-controlled substance, making it unique among prescription sleep medications 2, 5
  • The FDA approval contains no limitation on duration of prescription, though clinical guidelines recommend regular reassessment 2

Mechanism Distinguishing It From Other Sleep Medications

  • Ramelteon acts as a selective MT₁/MT₂ melatonin receptor agonist rather than through GABA-ergic sedation like traditional hypnotics 1, 6
  • It functions as a "chronohypnotic" working on the suprachiasmatic nucleus (the body's master clock) rather than producing direct sedation 1, 2
  • This represents the first new therapeutic mechanism for prescription insomnia medication in over three decades 1

References

2
Research

A review of ramelteon in the treatment of sleep disorders.

Neuropsychiatric disease and treatment, 2008

5
Guideline

Insomnia Treatment with Ramelteon and Quetiapine

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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