From the Research
Effectiveness of Rocephin (Ceftriaxone) Against Dental Infections
- Ceftriaxone has been shown to be effective against a broad range of bacteria, including those that cause dental infections 1, 2, 3.
- A study comparing the sensitivity of bacteria isolated in odontogenic infections to ceftriaxone and amoxicillin-clavulanate found that 70% of isolated organisms were sensitive to ceftriaxone, making it a potentially effective treatment option for dental infections 3.
- Ceftriaxone has been found to be effective in treating skin and soft tissue infections, which can be related to dental infections 4.
- The drug has a long half-life, allowing for once-daily administration, which can be beneficial for patients with dental infections 1, 4.
Spectrum of Activity
- Ceftriaxone has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria 1, 2.
- It is effective against Enterobacteriaceae, nonenterococcal streptococci, and Haemophilus influenzae 2.
- However, it is generally inactive against enterococci and methicillin-resistant staphylococci 2.
- Ceftriaxone has moderate activity against Pseudomonas aeruginosa, but its use as sole antibiotic therapy in pseudomonal infections is not recommended 1, 5.
Clinical Efficacy
- Ceftriaxone has been shown to be clinically effective in treating various infections, including urinary tract infections, skin and soft tissue infections, and respiratory tract infections 1, 5.
- A study found that ceftriaxone was effective in eradicating the pathogen in 85.1% of cases and resulted in an excellent clinical response in 75.6% of cases 5.
- However, the use of ceftriaxone in dental infections should be based on the results of antibiotic sensitivity testing to ensure effective treatment 3.