What is the equivalent dose of Adderall (mixed‑amphetamine salts) for Vyvanse (lisdexamfetamine) 30 mg?

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Adderall Equivalent Dose for Vyvanse 30 mg

Start with Adderall XR 10-15 mg once daily in the morning when converting from Vyvanse 30 mg, as this represents approximately a 2:1 conversion ratio based on the prodrug conversion mechanism and clinical dosing guidelines. 1

Conversion Rationale

  • Vyvanse (lisdexamfetamine) is a prodrug that undergoes enzymatic hydrolysis in the blood to release dextroamphetamine, with the l-lysine amino acid cleaved off through rate-limited conversion 1, 2

  • The conversion from Vyvanse 70 mg to Adderall XR 30 mg (approximately a 2.3:1 ratio) provides the framework for proportional dosing, meaning Vyvanse 30 mg would convert to approximately 10-15 mg of Adderall XR 1

  • Lisdexamfetamine produces a lower peak plasma concentration (Cmax) and extended time to peak (Tmax) compared to an equivalent dose of immediate-release amphetamine, which explains why lower Adderall doses are needed 3

Practical Dosing Options

Extended-Release Formulation (Preferred)

  • Begin with Adderall XR 10 mg once daily in the morning and titrate upward in 5 mg increments weekly based on clinical response 1
  • Adderall XR provides approximately 12 hours of coverage with a biphasic release mechanism (50% immediate, 50% delayed by 4 hours) 4

Immediate-Release Formulation (Alternative)

  • Start with 5 mg twice daily (10 mg total daily dose) if using immediate-release Adderall 1
  • Titrate upward in 5 mg increments weekly, with typical dosing reaching 10-15 mg twice daily (20-30 mg total) 1

Monitoring During Conversion

  • Watch for breakthrough symptoms in the late afternoon/evening, as Vyvanse provides up to 13-14 hours of therapeutic action compared to Adderall XR's 12-hour duration 1, 3

  • Monitor for side effects including insomnia, decreased appetite, increased blood pressure and heart rate during the conversion period 1

  • The therapeutic effects should be apparent within 1.5 hours of the first Adderall dose, similar to other stimulants 4

Critical Caveats

  • Do not use strict mathematical conversion formulas—individual patient factors significantly affect optimal dosing, and clinical response should guide final titration 1

  • The conversion ratio is not 1:1 because lisdexamfetamine's prodrug mechanism results in lower peak amphetamine concentrations and reduced inter-individual variability compared to direct amphetamine administration 5, 3

  • Avoid assuming equivalent efficacy at any particular dose ratio, as individual response varies significantly even within the same medication class 6

References

1
Guideline

Adderall Equivalent Dosing to Lisdexamfetamine 70 mg

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

2
Research

Lisdexamfetamine.

Paediatric drugs, 2007

6
Guideline

Converting Vyvanse to Concerta

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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