From the Research
Vancomycin and C. diff Infection
- Vancomycin is a commonly used treatment for Clostridioides difficile (C. diff) infection, and its efficacy has been studied in several trials 1, 2, 3, 4, 5.
- The use of vancomycin for C. diff infection has been shown to be effective, with studies demonstrating its superiority over metronidazole in severe cases 1 and its non-inferiority to fidaxomicin in clinical cure rates 3.
- However, the optimal dosing regimen for vancomycin in the treatment of C. diff infection is still a topic of debate, with some studies suggesting that high-dose vancomycin may not be necessary for all patients 2, 5.
Nitrofurantoin and C. diff Infection
- There is limited evidence available on the use of nitrofurantoin in the treatment of C. diff infection.
- None of the provided studies specifically address the use of nitrofurantoin for C. diff infection, and therefore, it is unclear whether nitrofurantoin can exacerbate C. diff infection.
Exacerbation of C. diff Infection
- The provided studies do not suggest that vancomycin exacerbates C. diff infection, but rather that it is an effective treatment for the infection 1, 2, 3, 4, 5.
- However, the use of vancomycin has been shown to have a potential impact on the risk of vancomycin-resistant Enterococci (VRE), although one study found that oral vancomycin did not increase the risk of VRE compared to metronidazole 4.
- Without further evidence, it is unclear whether nitrofurantoin can exacerbate C. diff infection.