Is there a surgical procedure called red blood cell (RBC) stroma surgery?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: February 6, 2026View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

RBC Stroma Surgery Does Not Exist as a Surgical Procedure

There is no recognized surgical procedure called "RBC stroma surgery" in medical practice. This term does not appear in any surgical, hematologic, or transfusion medicine literature.

What You May Be Asking About

If Referring to Corneal Stromal Surgery

The term "stroma" in surgery most commonly refers to corneal stroma, not red blood cell stroma. Several established corneal stromal procedures exist:

  • Deep Anterior Lamellar Keratoplasty (DALK): Removes all or nearly all corneal stroma for visual rehabilitation, preserving the patient's Descemet's membrane and endothelium 1
  • Anterior Lamellar Keratectomy (ALK): Removes visually significant anterior stromal opacities using microblade, excimer laser, or femtosecond laser 1
  • Phototherapeutic Keratectomy (PTK): Ablates preprogrammed depth of superficial and anterior stromal lesions 1

These procedures achieve graft survival rates of 93.9% at 5 years for DALK versus 80.4% for full-thickness penetrating keratoplasty 1.

If Referring to Red Blood Cell Transfusion in Surgery

Red blood cells are transfused as a therapeutic procedure, not surgically manipulated. Current transfusion guidelines recommend:

  • Restrictive threshold of 8 g/dL hemoglobin is safe for most surgical patients, including brain tumor surgery 1
  • Threshold of 10 g/dL may be indicated in patients with hemodynamic challenges during surgical resection 1
  • Do not transfuse based solely on laboratory values without considering clinical patient variables 1
  • Transfuse immediately for hemorrhagic shock regardless of hemoglobin level 2

The American Association of Blood Banks recommends following standard restrictive transfusion thresholds rather than liberal transfusion practices, as restrictive approaches reduce morbidity without compromising outcomes 2.

Common Pitfall to Avoid

Do not confuse RBC stroma (the internal protein scaffold of red blood cells) with corneal stroma (the middle layer of the cornea). These are completely different anatomical structures requiring entirely different medical interventions 1.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Management of Elevated Nucleated Red Blood Cells (NRBCs) in Adults

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.