From the FDA Drug Label
There are no available data on the presence of fluticasone propionate or salmeterol in human milk, the effects on the breastfed child, or the effects on milk production. However, fluticasone propionate and salmeterol concentrations in plasma after inhaled therapeutic doses are low and therefore concentrations in human breast milk are likely to be correspondingly low The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for AIRDUO RESPICLICK and any potential adverse effects on the breastfed child from AIRDUO RESPICLICK or from the underlying maternal condition.
The use of Advair (fluticasone propionate and salmeterol) with milk (breastfeeding) has limited data.
- Key points:
- No available data on presence in human milk
- Low concentrations in plasma, likely low in breast milk
- Consider developmental benefits of breastfeeding and potential adverse effects on the breastfed child Based on the limited information, it is recommended to exercise caution when using Advair in breastfeeding mothers, weighing the benefits of breastfeeding against the potential risks to the infant 1.
From the Research
It is recommended to rinse your mouth with water after using Advair (fluticasone/salmeterol) and wait at least 30 minutes before consuming milk or dairy products to minimize the risk of thrush and ensure proper medication absorption. When using Advair, it's essential to follow proper mouth-rinsing techniques to prevent fungal infections like thrush, which can develop in the mouth and throat as a side effect of the corticosteroid component (fluticasone) in Advair 2.
Key Considerations
- Rinsing your mouth with water after using Advair helps prevent thrush by removing any medication residue that may be present in the mouth and throat.
- Waiting at least 30 minutes before consuming milk or dairy products allows the medication to be absorbed properly and reduces the risk of thrush.
- Dairy products can coat the throat and mouth, potentially trapping medication residue against the tissues and increasing the risk of thrush.
Additional Information
- The combination of fluticasone propionate and salmeterol in Advair has been shown to be effective in improving lung function and symptoms in patients with asthma 3, 4, 5.
- The most recent study on the topic, published in 2025, highlights the importance of proper inhaler technique and adherence to treatment in achieving optimal outcomes in patients with COPD 6.
- However, it's essential to note that this study focused on COPD, not asthma, and the findings may not be directly applicable to patients using Advair for asthma.
Practical Advice
- If you're using Advair as prescribed and following proper mouth-rinsing techniques, you can resume consuming milk and dairy products after waiting about 30 minutes.
- It's crucial to prioritize proper medication use and adherence to treatment to minimize the risk of side effects and ensure optimal outcomes.