From the Research
Association with Diabetes Mellitus
- Kratom (Mitragyna speciosa) has been used to reduce blood sugar and lipid profiles in traditional medicine, with mitragynine being a major constituent in kratom leaves 1.
- The ethanol extract of kratom exhibited the strongest inhibition activity against α-glucosidase and pancreatic lipase, with mitragynine showing the most potent α-glucosidase inhibition 1.
- These results suggest the potential of mitragynine from kratom as a herbal supplement for the treatment and prevention of diabetes mellitus 1.
Association with Pancreatic Disorders
- There is limited information on the association between kratom and pancreatic disorders, but the inhibition of pancreatic lipase by mitragynine may have implications for pancreatic function 1.
- No direct evidence is available to suggest a link between kratom use and pancreatic disorders, but further research is needed to fully understand the potential effects of kratom on the pancreas.
General Health Effects of Kratom
- Kratom has been associated with various adverse health effects, including hepatic, cardiac, and CNS effects, as well as potential drug-drug interactions 2, 3, 4.
- The use of kratom has been linked to multiorgan toxicity and cardiotoxicity, including ventricular arrhythmia and cardiopulmonary arrest, particularly when co-administered with other substances 5.
- However, the current evidence suggests that kratom may have therapeutic potential in some individuals, and products present few risks with typical, non-polysubstance use 3.