What is Hexarelin 6 mg?

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Hexarelin 6mg: Experimental Growth Hormone Secretagogue

Hexarelin is a synthetic growth hormone-releasing peptide (GHRP) that stimulates growth hormone (GH) release through specific receptors in the pituitary and hypothalamus, but it is NOT FDA-approved for any clinical indication and should not be used in routine medical practice. 1, 2

Pharmacological Profile

Mechanism of Action:

  • Hexarelin binds to and activates the growth hormone secretagogue receptor (GHSR) in both the brain and peripheral tissues, including the heart and blood vessels 3
  • It also binds to the non-GHSR receptor CD36 in cardiac tissue, which mediates potential cardioprotective effects 3
  • The compound is chemically more stable than natural ghrelin and functionally more potent as a GH secretagogue 3

Hormonal Effects Beyond GH:

  • Hexarelin stimulates prolactin (PRL) release at levels similar across all age groups (approximately 500-600 μg*min/L) 1
  • It possesses significant ACTH and cortisol-releasing activity comparable to corticotropin-releasing hormone (CRH), with ACTH responses ranging from 1,200-2,250 pg*min/mL depending on age 1, 4
  • The ACTH-releasing effect appears independent of both CRH and vasopressin pathways, as hexarelin shows no synergistic interaction with these neurohormones 4

Age-Dependent GH Response Patterns

The GH response to hexarelin varies dramatically with age:

  • Prepubertal children: moderate response (approximately 770 μg*min/L) 1
  • Pubertal adolescents: peak response (approximately 1,960 μg*min/L, 2.5-fold higher than prepubertal) 1
  • Young adults: sustained high response (approximately 1,830 μg*min/L, similar to pubertal) 1
  • Elderly adults: reduced response (approximately 950 μg*min/L, returning to prepubertal levels) 1

Dosing Information from Research Studies

Experimental doses studied in humans:

  • The maximal effective dose studied was 2.0 μg/kg intravenously, which translates to approximately 140 μg for a 70 kg adult 1, 4
  • A 6mg dose would represent approximately 85 μg/kg for a 70 kg person—over 40 times the studied maximal effective dose 1
  • In animal studies, subcutaneous administration produced longer-lasting GH release than intravenous administration 2

Repeated dosing effects:

  • A second bolus of hexarelin administered 60-120 minutes after the first produces significant additional GH secretion, but with reduced peak secretion rates when given at 120 minutes (P=0.03) 5
  • The synergistic effect observed when hexarelin is combined with GHRH is lost upon repeated administration 5

Critical Safety and Regulatory Considerations

This compound lacks FDA approval and clinical safety data:

  • No evidence exists in the provided literature regarding the safety, efficacy, or appropriate use of a 6mg dose in humans
  • The cardiovascular effects through CD36 receptors are incompletely characterized and may pose unknown risks 3
  • The simultaneous stimulation of ACTH/cortisol could lead to hypercortisolism with chronic use 1, 4

Common pitfall: Hexarelin is sometimes marketed through non-medical channels as a "research peptide" or performance-enhancing substance. Clinicians should not prescribe this compound, as it has no established therapeutic indication, no FDA approval, and no safety data at the 6mg dose level.

If a patient presents requesting or using hexarelin, counsel them that this represents use of an unapproved experimental compound with unknown risks, and redirect them toward evidence-based, FDA-approved treatments for their underlying condition (whether growth hormone deficiency, aging-related concerns, or athletic performance enhancement).

References

3
Research

The cardiovascular action of hexarelin.

Journal of geriatric cardiology : JGC, 2014

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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