What is the cause of sudden onset of madarosis (loss of eyelashes) in a 7-year-old female?

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Differential Diagnosis for a 7-year-old Girl with Random Onset of Eye Lash Loss

  • Single most likely diagnosis:
    • Alopecia areata: This is an autoimmune condition that can cause hair loss on any part of the body, including the eyelashes. It is relatively common in children and can have a sudden onset.
  • Other Likely diagnoses:
    • Blepharitis: This is an inflammation of the eyelids that can cause eyelash loss, among other symptoms like redness and itching.
    • Demodex infestation: Demodex mites can live on the eyelashes and cause loss, especially if there is an overpopulation.
    • Trichotillomania: This is a psychological condition where a person pulls out their own hair, including eyelashes, often due to stress or anxiety.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.):
    • Thyroid disorders: Both hypothyroidism and hyperthyroidism can cause hair loss, including eyelashes. Although less common, thyroid disorders can have significant health implications if not treated.
    • Systemic lupus erythematosus (SLE): This autoimmune disease can cause a wide range of symptoms, including hair loss. Early diagnosis and treatment are crucial to prevent serious complications.
  • Rare diagnoses:
    • Leukemia or lymphoma: Certain types of cancer can cause hair loss, including eyelashes, due to the disease itself or the treatment.
    • Congenital or genetic conditions: Conditions like congenital alopecia or genetic disorders affecting hair growth can cause eyelash loss, though these would typically be present from birth or early infancy.
    • Sjögren's syndrome: This autoimmune disorder can cause dry eyes and mouth, and in some cases, hair loss, including eyelashes. It is rare in children but can have significant implications if not managed properly.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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