What is the medical term for a cyst located in the natal cleft of the buttocks?

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Medical Term for a Cyst on the Buttocks

A cyst located in the natal cleft (the groove between the buttocks) is called a pilonidal cyst or pilonidal sinus disease. 1, 2

Definition and Location

Pilonidal cyst disease is an acquired inflammatory condition that predominantly affects the natal cleft of the buttocks. 3 The term "pilonidal" literally refers to a nest of hair, and these cysts characteristically occur in the sacrococcygeal region—the area at the base of the spine where the buttocks meet. 2, 4

Key Distinguishing Features

The location is critical for proper identification:

  • Pilonidal cysts are located in the natal cleft (the groove between the buttocks), typically in the sacrococcygeal region 2, 3
  • These should be distinguished from simple sacral dimples, which have different clinical significance based on their exact location 5
  • The disease predominantly affects young men, with a male-to-female ratio of 3-4:1, typically presenting toward the end of the second decade of life 3

Clinical Presentation

Pilonidal cysts present along a spectrum:

  • Initially asymptomatic pits or small midline openings 2
  • May progress to painful, draining lesions when complications like abscess formation develop 3
  • Additional lateral sinus openings are frequently present 2
  • The sinus is initiated from a small midline opening lined by stratified squamous epithelium 2

Important Differential Considerations

When evaluating a cyst in the buttock region, consider these alternatives in your differential diagnosis:

  • Recurrent cutaneous abscesses, hidradenitis suppurativa, folliculitis, furuncles, and perianal fistulas 1
  • Sacral dimples (coccygeal vs. lumbosacral)—these require different management 5
  • Dermoid cysts or subcutaneous masses associated with dermal sinus tracts 6, 5

Common Pitfall to Avoid

Do not confuse benign coccygeal dimples (located below an imaginary line connecting the tops of the gluteal cleft) with pathologic lumbosacral dermal sinus tracts (located above this line on the flat part of the sacrum). 5 While pilonidal cysts occur in the natal cleft itself, lumbosacral dermal sinus tracts are located higher on the sacrum and require immediate neurosurgical referral due to risk of CNS infection and other serious complications. 6, 5

References

Guideline

Diagnostic and Management of Pilonidal Cysts

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

Research

Dermoscopy of Pilonidal Cyst Disease: A Case-series.

Acta dermatovenerologica Croatica : ADC, 2022

Research

Pilonidal cyst: cause and treatment.

Diseases of the colon and rectum, 2000

Guideline

Referral Pathway for Infants with Sacral Dimples

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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