A 32-year-old male presents with a 2-week history of nasal congestion and drainage, associated with hand-foot-and-mouth disease, now experiencing worsening symptoms including fever, sinus pressure, and tenderness over the maxillary and frontal sinuses, despite taking Tylenol (acetaminophen)?

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Differential Diagnosis

  • Single most likely diagnosis
    • Acute bacterial sinusitis: The patient's symptoms of increasing nasal congestion, sinus pressure, and fever over the past 2 days, along with tenderness over the maxillary and frontal sinus, are consistent with acute bacterial sinusitis. The recent history of hand-foot-and-mouth disease may have predisposed him to secondary bacterial infection.
  • Other Likely diagnoses
    • Viral sinusitis: Given the patient's initial symptoms of nasal congestion and drainage, viral sinusitis is a possible diagnosis. However, the increasing severity of symptoms and fever suggest a possible secondary bacterial infection.
    • Influenza: The patient's symptoms of fever, nasal congestion, and sinus pressure could be consistent with influenza, especially during the flu season.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Meningitis: Although the patient's neck stiffness has improved, it is essential to consider meningitis, especially given the initial symptom. However, the absence of other symptoms like severe headache, photophobia, and altered mental status makes it less likely.
    • Orbital cellulitis: The patient's symptoms of sinus pressure and tenderness over the maxillary and frontal sinus could be indicative of orbital cellulitis, which is a serious infection that requires prompt treatment.
  • Rare diagnoses
    • Sinusitis caused by atypical organisms (e.g., fungal sinusitis): Although rare, fungal sinusitis can occur, especially in immunocompromised patients. However, there is no indication of immunocompromise in this patient.
    • Lemierre's syndrome: This is a rare condition characterized by bacterial pharyngitis followed by septic thrombophlebitis of the internal jugular vein. Although the patient has a history of hand-foot-and-mouth disease, there is no indication of pharyngitis or other symptoms suggestive of Lemierre's syndrome.

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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