What is the ideal preconception serum ferritin range (and target hemoglobin) for a woman planning pregnancy?

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Ideal Iron/Ferritin Levels for Preconception Planning

Women planning pregnancy should aim for a serum ferritin level above 30 μg/L, ideally above 70 μg/L, to ensure adequate iron stores for the increased demands of pregnancy. 1, 2

Target Ferritin Ranges Before Conception

The optimal preconception ferritin level depends on your starting iron stores, as approximately 40% of women of reproductive age have ferritin ≤30 μg/L, representing unfavorable iron status for pregnancy 1, 2:

Ferritin-Based Supplementation Strategy

  • Ferritin >70 μg/L: No iron supplementation needed beyond standard prenatal vitamin (27 mg elemental iron) 1

  • Ferritin 31-70 μg/L: Start 30-40 mg ferrous iron daily for 2-3 months before conception 1

  • Ferritin ≤30 μg/L: Start 60-100 mg ferrous iron daily for 3-6 months before conception 1

  • Ferritin <15 μg/L: Indicates depleted iron reserves; requires therapeutic doses of 100 mg ferrous iron daily 2

Why These Targets Matter

Adequate iron status at conception requires body iron reserves ≥500 mg, but only 15-20% of women naturally have stores of this magnitude. 2, 3 This is critical because:

  • Iron requirements increase dramatically during pregnancy, from 0.8 mg/day in the first trimester to 7.5 mg/day in the third trimester 2, 4

  • Women beginning pregnancy with depleted iron stores (ferritin <12 μg/L) deliver babies weighing on average 192 grams less, even when supplemented with moderate daily iron during pregnancy 5

  • Iron deficiency increases risk of preterm delivery, prematurity, and small-for-gestational-age birthweight 2

Hemoglobin Targets

While ferritin is the most specific indicator of iron stores 1, hemoglobin should be maintained in the normal range for non-pregnant women (≥12 g/dL) 6. However, ferritin is far more important than hemoglobin for preconception assessment, as hemoglobin alone is inadequate for detecting iron deficiency 1.

Practical Implementation

Check ferritin levels before attempting conception to identify women who need supplementation. 1 This is essential because:

  • More than 90% of Scandinavian women have dietary iron intake below the recommended 15 mg/day 2

  • Only about one-fourth of women of childbearing age meet recommended dietary allowance for iron through diet alone 7

  • Women lose an average of 0.3-0.5 mg iron daily through menstruation, with 10% experiencing heavy menstrual bleeding (>80 mL/month) that significantly increases iron loss 7

Special Considerations

For women with hemochromatosis planning pregnancy, the approach differs: avoid iron deficiency but maintain ferritin >45 μg/L by reducing phlebotomy intensity, as iron deficiency poses risks for adverse maternal and fetal outcomes. 6

Take iron supplements between meals for optimal absorption, and continue supplementation for the full recommended duration (2-6 months depending on initial ferritin level) before conception. 2

References

Guideline

Iron Supplementation Guidelines for Pregnancy

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

Research

Iron requirements in pregnancy and strategies to meet them.

The American journal of clinical nutrition, 2000

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Ferritin Decrease During Menstruation

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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