From the Guidelines
Recommended Dosage of Prednisone for Severe Atopic Dermatitis Flare
For severe atopic dermatitis flare, a prednisone prescription of 0.5-1.0 mg/kg/day, not to exceed 60 mg/day, is recommended for a limited duration of 7-14 days 1.
- The dose should be tapered by 5-10 mg every 2-3 days to minimize rebound flare.
- Alternatively, a burst of 40-50 mg/day for 3-5 days may be considered for acute, severe flares, followed by a rapid taper. The use of systemic corticosteroids like prednisone should be reserved exclusively for acute, severe exacerbations and as a short-term bridge therapy to other systemic, corticosteroid-sparing therapy 1.
- It is essential to note that while prednisone can be effective in managing severe atopic dermatitis flares, its use should be carefully considered due to potential side effects and the availability of other treatment options.
- The dosage and duration of prednisone treatment should be individualized based on the patient's response and medical history.
- A tapering schedule is crucial to decrease the risk of adrenal suppression and rebound flare 1.
From the FDA Drug Label
The initial dosage of PredniSONE tablets may vary from 5 mg to 60 mg per day, depending on the specific disease entity being treated. IT SHOULD BE EMPHASIZED THAT DOSAGE REQUIREMENTS ARE VARIABLE AND MUST BE INDIVIDUALIZED ON THE BASIS OF THE DISEASE UNDER TREATMENT AND THE RESPONSE OF THE PATIENT
The recommended dosage of prednisone for a severe atopic dermatitis (eczema) flare is not explicitly stated in the drug label. However, the label suggests that the initial dosage may vary from 5 mg to 60 mg per day, depending on the disease entity being treated, and that dosage requirements must be individualized based on the disease and patient response 2.
- The dosage should be adjusted until a satisfactory response is noted.
- Constant monitoring is needed to determine the proper maintenance dosage.
- The label does not provide a specific dosage recommendation for severe atopic dermatitis.
From the Research
Recommended Dosage of Prednisone for Severe Atopic Dermatitis
- The recommended dosage of prednisone for severe atopic dermatitis is not directly stated in the provided studies 3, 4, 5, 6.
- However, study 4 mentions that European guidelines propose a 0·5 mg kg-1 per day dose of oral prednisone as initial treatment for bullous pemphigoid, which is a different skin condition.
- Study 6 compares the safety and effectiveness of doxycycline and oral prednisolone (0.5 mg/kg/day) for initial treatment of bullous pemphigoid, but does not provide information on atopic dermatitis.
- Study 3 discusses the use of lower dose prednisone for acute graft-versus-host disease, with doses ranging from 0.5 mg/kg/day to 2 mg/kg/day, but this is not relevant to atopic dermatitis.
- Study 5 is focused on the use of isotretinoin for acne treatment and does not provide information on prednisone dosage for atopic dermatitis.
Dosage Considerations
- The dosage of prednisone may vary depending on the severity of the condition, patient age, and other factors.
- It is essential to consult a healthcare professional to determine the appropriate dosage of prednisone for severe atopic dermatitis, as they can assess individual patient needs and provide personalized guidance 4, 6.