Does the Kadono et al. Study Indicate ADT-Induced Penile Shrinkage is Reversible?
The provided evidence does not contain the Kadono et al. study on penile size changes with androgen deprivation therapy, so I cannot answer whether that specific paper suggests reversibility of penile shrinkage.
What the Available Evidence Shows About ADT Side Effects
The available guidelines and research discuss various adverse effects of ADT but do not specifically address penile size changes or their reversibility:
Known Sexual and Physical Effects of ADT
Sexual dysfunction is a well-established consequence of ADT, including decreased libido, erectile dysfunction, and reduced frequency of spontaneous erections, with these effects persisting throughout treatment 1.
Body composition changes occur with long-term ADT, including increased fat mass and decreased lean body mass, which develop after at least 12 months of treatment 1.
Potential for Recovery with Intermittent ADT
Intermittent ADT allows for off-treatment periods during which testosterone recovery may occur, potentially mitigating some adverse effects 2, 3.
Quality of life improvements with intermittent therapy include better erectile function and mental health at 3 months off treatment compared to continuous ADT, though these differences may diminish over time 4.
The duration and extent of testosterone recovery during off-treatment periods influences quality of life outcomes with intermittent ADT, suggesting some reversibility of androgen-dependent effects 2.
Critical Gap in Evidence
The specific question about penile size changes and their reversibility cannot be addressed without access to the Kadono et al. study. To properly answer this question, I would need the actual Kadono et al. publication that directly measured penile dimensions in patients receiving versus not receiving ADT.