From the FDA Drug Label
USUAL DOSAGE: Apply to affected area 2 or 3 times daily. The typical nystatin powder dosing regimen for under breast fold rash would be to apply to the affected area 2 or 3 times daily. Other pharmacological measures that should be employed for breast fold rashes include:
- keeping the area clean and dry
- using an antifungal cream or ointment Non-pharmacological measures include:
- wearing loose, breathable clothing
- avoiding irritants and allergens
- maintaining good hygiene 1
From the Research
For under breast fold rash, nystatin powder is typically applied 2-3 times daily after thoroughly cleaning and drying the area, with the standard application continuing for 7-14 days, and possibly 1-2 weeks beyond symptom resolution to prevent recurrence. The treatment of breast fold rashes, also known as intertrigo, involves a combination of pharmacological and non-pharmacological measures to reduce moisture, heat, and friction in the skin folds, which are conducive to fungal growth, particularly Candida. In addition to nystatin, other effective antifungal options include clotrimazole, miconazole, or ketoconazole creams applied twice daily 2. For moderate to severe cases, a low-potency topical steroid like hydrocortisone 1% may be added for 3-5 days to reduce inflammation.
Non-pharmacological measures are equally important and include:
- Keeping the area clean and dry
- Using absorbent cotton or specialized moisture-wicking fabrics between skin folds
- Changing bras daily
- Wearing cotton bras that fit properly
- Avoiding tight clothing
- Using absorbent powders (non-medicated) or placing a clean cotton cloth between skin folds to help maintain dryness
These measures are crucial as they create an inhospitable environment for fungal growth, while proper hygiene removes irritants and reduces microbial load. Although the provided studies do not directly address the treatment of under breast fold rash, the principles of antifungal treatment and prevention of fungal infections can be applied, as seen in studies such as 3 and 2, which discuss the use of nystatin and other antifungals in preventing fungal infections in various contexts.