From the FDA Drug Label
Cyclobenzaprine HCl relieves skeletal muscle spasm of local origin without interfering with muscle function.
The answer to the question about a cream for muscle spasms is that cyclobenzaprine is available as an oral medication, not a cream, and it relieves skeletal muscle spasm of local origin.
- Key points:
- It is ineffective in muscle spasm due to central nervous system disease.
- There is no mention of a cream formulation in the provided drug label 1.
From the Research
For muscle spasms, topical creams containing menthol, camphor, or methyl salicylate are often effective options, with menthol being a selective activator of transient receptor potential melastatin-8 (TRPM8) channels, as reported in a 2018 study 2. These creams work through different mechanisms, such as creating a cooling sensation that distracts from pain, reducing inflammation by blocking pain-causing chemicals, or temporarily numbing the area. Some products that can provide relief include IcyHot, Bengay, or Voltaren (diclofenac sodium 1%), which should be applied directly to the affected area 3-4 times daily. Key considerations when using these creams include:
- Massaging a thin layer into the skin until absorbed
- Avoiding broken skin
- Washing hands afterward
- Combining creams with gentle stretching, adequate hydration, and heat or cold therapy for best results It is essential to note that if muscle spasms persist beyond a week, worsen, or are accompanied by severe pain or weakness, consulting a healthcare provider is necessary, as this might indicate a more serious condition requiring different treatment, as discussed in various studies, including one from 2013 on the pharmacology of topical analgesics 3. Additionally, understanding the mechanisms of action of capsaicin, another potential ingredient in topical creams, can provide insights into its utility in various painful conditions, as reviewed in a 2013 study 4 and a 2011 study on the chemical and pharmacological aspects of capsaicin 5. However, the most recent and highest quality study on the topic, from 2018, highlights the role and mechanism of action of menthol in topical analgesic products 2, making it a preferred option for muscle spasms.