A 10-year-old girl presents to the emergency department with right lower quadrant abdominal pain, nausea, three episodes of vomiting, and rebound tenderness on examination. What is the most likely diagnosis?

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Diagnosis: Acute Appendicitis

The diagnosis is acute appendicitis (Answer A). This 10-year-old girl presents with the classic clinical triad: right lower quadrant pain with rebound tenderness, nausea, and vomiting—findings that strongly support appendicitis as the primary diagnosis. 1, 2

Why Appendicitis is the Correct Diagnosis

At 10 years old, this patient is in the peak age range for appendicitis, which most commonly occurs between ages 10-30 years. 1, 3 The clinical presentation is textbook:

  • Right lower quadrant pain with rebound tenderness indicates peritoneal irritation, the hallmark of appendicitis when the inflamed appendix contacts the parietal peritoneum. 2, 4
  • Nausea and vomiting are common presenting features in pediatric appendicitis. 2, 5
  • Physical examination findings of pain and rebound tenderness in the RLQ are among the best clinical signs for ruling in acute appendicitis. 4

The combination of these three features—RLQ pain, nausea/vomiting, and peritoneal signs—makes appendicitis the overwhelmingly most likely diagnosis. 2, 6

Why the Other Options Are Less Likely

Intussusception (Option B)

Intussusception is much more common in younger children, particularly those under 5 years of age, and is rare at 10 years old. 2, 7 The classic presentation differs significantly:

  • Intermittent colicky pain (not constant RLQ pain with rebound tenderness) 2, 7
  • Bloody stools ("currant jelly" stools) are characteristic 2
  • Typically presents with a palpable mass, not focal rebound tenderness 7

Meckel's Diverticulum (Option C)

Meckel's diverticulum typically presents differently:

  • Painless rectal bleeding is the most common presentation 5
  • When symptomatic, it more commonly causes obstruction or diverticulitis mimicking appendicitis, but this is less common than true appendicitis 5
  • The clinical presentation described (RLQ pain with rebound tenderness, nausea, vomiting) is classic for appendicitis, not Meckel's diverticulum 2, 6

Recommended Immediate Next Steps

Obtain ultrasound of the right lower quadrant immediately as the first-line imaging modality due to zero radiation exposure and good diagnostic accuracy in pediatric patients. 1, 7, 3

If ultrasound is equivocal or non-diagnostic and clinical suspicion remains high (as it should in this case), proceed directly to CT abdomen/pelvis with IV contrast or MRI, which provide 90-94% sensitivity and 94-98% specificity for appendicitis. 1, 3

Critical Pitfall to Avoid

Do not delay surgical consultation while waiting for imaging in a patient with this classic presentation. 4 The combination of RLQ pain, rebound tenderness, and vomiting in a 10-year-old warrants immediate surgical evaluation, as prolonged delay increases perforation risk from 17-32%. 4 Clinical examination findings this clear should prompt urgent action even as imaging is being arranged. 1, 2

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Diagnostic Considerations for Appendicitis in Young Population

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

Guideline

Acute Appendicitis Diagnosis and Management

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

Research

Acute Appendicitis: Efficient Diagnosis and Management.

American family physician, 2018

Research

Acute appendicitis.

Journal of paediatrics and child health, 2017

Guideline

Diagnosing Right Lower Quadrant Abdominal Pain in Children

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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