Injectable Meperidine (Demerol) Dosing for Adults
I cannot provide dosing recommendations for "Inj.Demed" (injectable Demerol/meperidine) because none of the provided evidence contains information about meperidine dosing or administration. The evidence includes guidelines on various other medications (amikacin, hydroxyzine, mannitol, chlordiazepoxide, and others) but does not address meperidine/Demerol specifically.
What the Evidence Does NOT Support
The search results contain:
- Antiretroviral therapy guidelines 1
- Non-tuberculous mycobacterial treatment protocols 1
- Pediatric emergency medications (but not meperidine) 1
- Cardiovascular life support drugs 1
- Tuberculosis treatment 1
- Immunization guidelines 1
- Mannitol dosing for cerebral edema 2
- Hydroxyzine and chlordiazepoxide dosing 3, 4
- Research on adrenal function and other unrelated topics 5, 6, 7, 8, 9
Clinical Guidance Needed
To provide accurate dosing recommendations for injectable meperidine in adults, I would need:
- FDA-approved drug labeling for meperidine
- Current pain management guidelines that specifically address meperidine dosing
- Evidence on appropriate dose ranges for different indications (acute pain, procedural sedation, etc.)
- Renal and hepatic dosing adjustments
- Maximum daily dose limits
- Contraindications and warnings specific to meperidine
Without this specific evidence, I cannot make a safe dosing recommendation. Meperidine has significant safety concerns including neurotoxic metabolite accumulation (normeperidine), seizure risk, and is generally not recommended as a first-line analgesic in modern practice. Consultation with current drug references and pain management guidelines is essential before prescribing this medication.