What are the likely causes of arm pain after an intravenous hydration infusion and how should it be assessed and managed?

Arm Pain After IV Hydration

Arm pain following IV hydration is most commonly caused by infiltration (fluid leaking into surrounding tissue), phlebitis (vein inflammation), or hematoma formation from vessel injury during cannulation, and requires immediate assessment to prevent progression to tissue damage or thrombosis. 1

Immediate Assessment Steps

When a patient reports arm pain after IV hydration, stop the infusion immediately to prevent progression of complications 1. The key is to rapidly differentiate between the three most common causes:

Clinical Presentation by Cause

Infiltration presents with:

• Swelling, bruising, and pain at or around the IV site 2
• The needle tip has perforated the vein wall, allowing fluid to leak into tissue 2
• Pain is often the first sign that patients notice 3
• May progress to tissue necrosis if unrecognized 3, 4

Hematoma manifests with:

• Obvious discoloration and swelling 1
• Results from blood leaking around the puncture site during or after cannulation 2
• Can vary from small diffuse areas to large firm masses 2
• Large hematomas can compress vessels and cause thrombosis 2

Phlebitis (vein inflammation) presents with:

• Pain along the vein, redness, and warmth 5
• Occurs in approximately 31% of peripheral IV catheter placements 5
• Risk factors include female gender, forearm insertion, longer dwelling time, and antibiotic infusions 5, 6

Initial Management Algorithm

Step 1: Stop and Assess

• Stop the infusion immediately when swelling, pain, or redness is observed 1
• Leave the cannula in place initially only if you need to aspirate infiltrated fluid, then remove it promptly 1
• Position the patient flat with the exit site below heart level to reduce air embolism risk 7

Step 2: Apply Local Measures

• Apply ice to the affected area for 10-15 minutes 1
• Elevate the limb while monitoring for symptom progression 1
• If bleeding is present, apply direct pressure for at least 5 minutes, but never occlude the outflow distal to the bleeding site as this increases intraluminal pressure to arterial levels 2, 1

Step 3: Monitor for Progression

• Check vital signs (temperature, pulse, blood pressure, respiratory rate) every 4 hours to detect systemic complications 1, 7
• Document the extent of swelling, discoloration, and pain 2
• Reassess frequently for the first 24-48 hours 2

When to Escalate Care

Order urgent duplex ultrasound if:

• Unilateral arm swelling develops, indicating possible upper extremity deep vein thrombosis (UEDVT) 1
• Pain persists or worsens despite initial management 2

Order chest X-ray if:

• Patient develops dyspnea or chest wall pain to rule out air embolism or other complications 1, 7

Refer to vascular surgery if:

• A very large hematoma develops that may require CVC placement and deferral of further access attempts for up to 3 months 2
• Bleeding requires skin suture placement, which is highly suggestive of venous outflow stenosis 2
• Signs of limb-threatening ischemia develop (though rare with peripheral IV) 2

Prevention Strategies for Future Access

To minimize recurrence, implement these evidence-based practices:

• Select large veins in the forearm for peripheral administration, avoiding joints, inner wrist, lower extremities, or areas with poor venous access 1
• Use flexible cannulae rather than winged steel "butterfly" needles 1
• Consider Vialon catheters over Teflon, as phlebitis incidence is lower (27% vs 33%) 5
• Check for blood return before administering medications and regularly throughout infusions 1
• Avoid insertion around the elbow, which increases phlebitis risk 6
• Minimize the number of insertion attempts, as multiple attempts increase phlebitis rates 6

Critical Pitfalls to Avoid

• Never apply pressure distal to an infiltration site, as this increases intraluminal pressure and worsens the infiltration 1
• Never dismiss unilateral swelling as benign—it indicates obstruction requiring urgent evaluation for UEDVT 1
• Never delay assessment for potential complications such as air embolism or bleeding 7
• Do not underestimate infiltration as a "natural consequence" of IV therapy—every effort should be made to prevent it 8

Special Considerations

For patients requiring continued IV access:

• Avoid the affected arm until symptoms completely resolve 2
• If a large hematoma developed, wait up to 3 months before attempting access in that area 2
• Consider alternative access sites or central venous access if peripheral options are exhausted 7

Documentation requirements:

• Record the event details, including site appearance, interventions performed, and patient response 2
• Accurate documentation is vital for patient care continuity and potential litigation 3