From the Guidelines
An adult born in 1943 who never had measles immunization should consider getting a measles vaccination if they have never been immunized, as the presumption of natural immunity is not absolute and the risk of complications from measles increases with age. People born before 1957 are generally presumed to have natural immunity to measles because the disease was widespread before vaccines became available, but this presumption isn't absolute [ 1 ]. For those without documented evidence of immunity, the MMR (measles, mumps, rubella) vaccine is recommended, especially during outbreaks or before international travel [ 1 ]. The standard regimen is one dose of MMR vaccine for adults born before 1957 without evidence of immunity. Key points to consider include:
- The vaccine is safe for older adults and provides protection against a disease that can be particularly severe in adults [ 1 ].
- Measles can cause serious complications including pneumonia, encephalitis, and even death, with higher risks in older individuals.
- Side effects from the vaccine are typically mild and temporary, such as soreness at the injection site or low-grade fever.
- Before vaccination, the individual should consult with their healthcare provider to review their medical history and confirm this recommendation is appropriate for their specific health situation [ 1 ].
From the Research
Measles Vaccination for Adults Born in 1943
- The decision to vaccinate an adult born in 1943 who never had measles immunization depends on various factors, including their current health status and potential exposure to measles.
- According to a study published in 2023 2, the measles, mumps, and rubella (MMR) vaccine is generally safe for adolescents and adults, with serious outcomes being rare.
- However, the study also notes that non-serious outcomes, such as allergic reactions and arthropathy, can occur, and vaccinees should be counseled regarding anticipated local and systemic adverse events.
- Another study published in 2025 3 investigates the immunogenicity and safety of MMR vaccine delivered by different routes in previously vaccinated young adults, but does not provide direct evidence for adults born in 1943.
- A study published in 2024 4 examines the effects of vaccination status and age on clinical characteristics and severity of measles cases in the United States, and finds that breakthrough measles cases tend to have milder disease with less complications.
- Two studies published in 2019 5, 6 investigate the long-term immunogenicity of MMR-containing vaccines in healthy young children and the durability of immune responses to measles and mumps following MMR vaccination, respectively, but do not provide direct evidence for adults born in 1943.
Considerations for Vaccination
- The risk of measles infection and complications should be weighed against the potential risks and benefits of vaccination.
- Adults born in 1943 who have never had measles immunization may still be at risk of infection, especially if they are exposed to measles in their daily lives.
- The MMR vaccine is generally safe and effective in preventing measles, mumps, and rubella, but individual circumstances should be taken into account when deciding whether to vaccinate.