What is a biphasic waveform in the tibial arteries and what is its clinical significance?

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Biphasic Waveforms in Tibial Arteries

Definition and Normal Arterial Flow Pattern

A biphasic waveform in the tibial arteries represents a two-phase Doppler velocity pattern consisting of a forward systolic flow component followed by a brief reverse flow component in early diastole, indicating relatively preserved arterial flow but suggesting some degree of increased peripheral resistance or early arterial disease. 1

  • In healthy individuals, tibial arteries typically demonstrate triphasic waveforms composed of three distinct phases: forward systolic flow, reverse flow in early diastole (due to peripheral resistance and elastic recoil), and forward diastolic flow. 2, 3

  • The triphasic pattern reflects normal arterial compliance, intact peripheral wave reflection, and adequate pulse pressure amplification from the aorta to the peripheral vessels. 2

Clinical Significance of Biphasic Flow

Biphasic waveforms indicate a transitional state between normal triphasic flow and abnormal monophasic flow, suggesting mild-to-moderate arterial disease or increased downstream resistance. 1, 4, 3

  • The loss of the third (forward diastolic) component transforms a triphasic into a biphasic pattern, which occurs when arterial stiffness increases, peripheral wave reflection diminishes, or pulse pressure amplification decreases. 2

  • Biphasic flow in tibial arteries can still provide adequate collateral support to ischemic regions, particularly when the reverse flow component remains robust, as demonstrated in patients with anterior tibial artery occlusion who maintain biphasic retrograde collateral flow from the posterior tibial artery via the plantar arch. 4

  • In the context of peripheral arterial disease (PAD), biphasic waveforms represent less severe hemodynamic impairment than monophasic flow, which indicates significant stenosis or occlusion with markedly dampened flow. 3

Interpretation in Clinical Context

When evaluating tibial artery waveforms, the progression from triphasic → biphasic → monophasic correlates with increasing severity of arterial occlusive disease and declining limb perfusion. 1, 3

  • Monophasic waveforms (single forward systolic component only) indicate significant proximal stenosis or occlusion and are associated with critical limb ischemia when accompanied by low peak systolic velocities. 4, 3

  • Doppler waveform analysis should be performed in conjunction with ankle-brachial index (ABI) measurements to accurately categorize arterial hemodynamics and functional impairment. 1, 3

  • The American College of Cardiology recommends that Doppler waveforms at the ankle serve as an adjunct to ABI, confirming concordance with the presence and severity of PAD and suggesting the presence of noncompressible arteries when discordance exists. 1

Prognostic Value

Patients with biphasic collateral flow to ischemic regions demonstrate better clinical outcomes than those with monophasic or absent retrograde flow. 4

  • In patients with critical atherosclerotic disease of the anterior tibial artery, posterior tibial artery-based biphasic or triphasic retrograde collateral flow prevents ischemia, whereas monophasic support or absent retrograde flow remains inadequate for tissue perfusion. 4

  • Among limbs with retrograde collaterals showing biphasic flow, only a minority experience claudication during walking, whereas limbs with diminished or absent retrograde filling demonstrate worse symptoms. 4

Practical Application in Vascular Assessment

Segmental pressures combined with pulse volume recordings (PVR) and Doppler waveforms are recommended to localize the anatomic level of disease when ABI is abnormal (<0.90). 1, 5

  • The American College of Cardiology assigns this combined approach a Class IIa recommendation for confirming concordance with PAD presence and severity. 1, 5

  • In patients with noncompressible vessels (ABI >1.40), waveform analysis becomes particularly valuable because it relies on flow characteristics rather than pressure measurements. 1

  • Peak systolic velocities in tibial arteries are significantly lower in PAD patients (peroneal: 34.3 cm/s, anterior tibial: 43.7 cm/s, posterior tibial: 43.4 cm/s) compared to controls (peroneal: 53.8 cm/s, anterior tibial: 65.4 cm/s, posterior tibial: 74.1 cm/s), and these velocity parameters help establish reference ranges for severe PAD versus normal limbs. 6

References

1
Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

4
Research

Defining the Collateral Flow of Posterior Tibial Artery and Dorsalis Pedis Artery in Ischemic Foot Disease: Is It a Preventing Factor for Ischemia?

Iranian journal of radiology : a quarterly journal published by the Iranian Radiological Society, 2016

5
Guideline

Diagnostic Approach to Peripheral Arterial Disease

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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