What is the appropriate oral cotrimoxazole (trimethoprim‑sulfamethoxazole) dosing for adults and children, including for prophylaxis and renal impairment?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: February 21, 2026View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Related Questions

Is Bactrim DS (Sulfamethoxazole/Trimethoprim) safe for a patient with impaired renal function (GFR of 29)?
What are the potential interactions between Ketorolac (Toradol) and sulfonamide (sulfa) medications?
What is the recommended dosing of Bactrim (trimethoprim/sulfamethoxazole) for an 86-year-old patient with impaired renal function (GFR of 49)?
What is the recommended treatment with Bactrim DS (Sulfamethoxazole/Trimethoprim) for a patient with a wound infection, considering their medical history and potential renal impairment?
Should the dose of trimethoprim-sulfamethoxazole (TMS-SMX) be adjusted in patients with impaired renal function?
Do patients in the continuation (maintenance) phase of anti‑tuberculosis therapy need isolation?
What are the efficacy percentages of the maternal RSVpreF vaccine (given at 32‑36 weeks gestation) and the infant monoclonal antibody nirsevimab (single dose at birth or within the first month) in preventing medically attended RSV lower‑respiratory‑tract infection and RSV‑related hospitalization in infants during the first 90 days to 4 months of life?
Should a patient with suspected polycythemia vera, marked leukocytosis and new altered mental status who cannot see hematology promptly be transferred to the emergency department for admission, and what emergent interventions are indicated?
What ceftriaxone dose should be given to an adult patient with osteomyelitis who has no β‑lactam allergy and normal renal and hepatic function?
What are the recommended fentanyl IV bolus and continuous infusion (perfusion) doses for opioid‑naïve adults, opioid‑tolerant adults, and pediatric patients?
What is the recommended dosing protocol for a continuous intravenous fentanyl infusion, including loading dose and maintenance rates, for opioid‑naïve and opioid‑tolerant adults and for pediatric patients?

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.