For a 30‑day titration requiring 69 × 200 mg capsules (maximum three capsules per day), can I prescribe a 90‑capsule bottle instead of a 60‑ or 100‑capsule bottle?

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Last updated: February 21, 2026View editorial policy

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Prescribing 90-Capsule Bottle for 30-Day Titration

Yes, you can prescribe a 90-capsule bottle for a 30-day titration requiring 69 capsules of 200 mg (maximum three capsules per day), as this provides adequate supply with minimal waste compared to prescribing a 60-capsule bottle (insufficient) or a 100-capsule bottle (excessive waste).

Practical Prescribing Logic

  • The 60-capsule bottle is insufficient for your titration schedule requiring 69 capsules total, leaving the patient 9 capsules short before completing the 30-day titration 1

  • The 90-capsule bottle provides exactly what you need with only 21 capsules remaining after the 69-capsule titration, which can serve as a buffer for missed doses or continuation if the patient tolerates the medication well 1

  • The 100-capsule bottle creates unnecessary waste with 31 unused capsules after the titration period, representing poor resource utilization and increased medication cost 2

Titration Schedule Considerations

  • Gradual dose escalation over 30 days with a maximum of three 200 mg capsules daily allows assessment of tolerability while minimizing adverse effects, consistent with standard titration principles for medications requiring dose adjustment 2, 3

  • The 90-capsule supply accommodates flexible titration if you need to slow the escalation due to side effects or hold at a lower dose temporarily before advancing 2

  • Most insurance formularies and pharmacy systems accept 90-day supplies as standard dispensing quantities, making this a routine prescription request 2

Documentation for Prior Authorization

  • Specify "90 capsules for 30-day titration protocol" on the prescription to clarify the medical necessity if questioned by pharmacy or insurance 2

  • Note the maximum daily dose of three capsules (600 mg total) to justify the quantity prescribed relative to the titration duration 1

  • Document that standard bottle sizes of 60 or 100 capsules do not align with your evidence-based titration schedule requiring exactly 69 capsules over 30 days 2

References

Guideline

Maximum Recommended Daily Dose of Buspar (Buspirone)

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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