From the Guidelines
Ozempic can cause migraines, as headaches are listed as a common side effect of the medication. According to the study published in Obesity Reviews in 2023 1, semaglutide, the active ingredient in Ozempic, has been associated with headaches, including migraines, in some patients. The study reports that headaches are a common side effect of semaglutide, affecting patients who are using the medication for chronic weight management.
Some key points to consider when evaluating the risk of migraines with Ozempic include:
- The medication's mechanism of action, which involves glucagon-like peptide-1 (GLP-1) analogs, may contribute to the development of headaches in some patients 1.
- The study suggests that headaches, including migraines, are a common side effect of semaglutide, but the exact incidence is not specified 1.
- Patients who experience new or worsening headaches after starting Ozempic should discuss this with their healthcare provider, who may recommend strategies to manage these symptoms, such as staying well-hydrated or adjusting the dosing schedule 1.
It is essential to weigh the potential benefits of Ozempic against the risk of migraines and other side effects, considering the individual patient's medical history and health status. Healthcare providers should closely monitor patients who experience headaches or migraines while taking Ozempic and adjust the treatment plan as needed to minimize the risk of adverse effects.
From the Research
Ozempic and Migraines
- There is no direct evidence in the provided studies that Ozempic (semaglutide) causes migraines.
- The studies focus on the effects of semaglutide on type 2 diabetes, obesity, and peripheral artery disease, as well as its safety and tolerability profile 2, 3, 4, 5, 6.
- Common adverse events associated with semaglutide include gastrointestinal disorders, such as nausea and diarrhea, but migraines are not specifically mentioned as a side effect 3, 4, 6.
- One study notes that semaglutide has anti-inflammatory properties, which could potentially have an impact on migraine pathophysiology, but this is speculative and not directly addressed in the studies 2.