From the Guidelines
Semaglutide can potentially make some people feel cold, although this is not a commonly reported side effect in clinical trials 1. This medication, sold under brand names like Ozempic, Wegovy, and Rybelsus, works by mimicking a hormone called GLP-1 that regulates blood sugar and appetite. The sensation of feeling cold is not listed as a common side effect in the medication's official labeling, but some patients do report experiencing this symptom. The mechanism behind this cold sensation might be related to semaglutide's effects on metabolism and weight loss, as seen in the STEP trials, where participants experienced significant weight loss 1. As the body loses fat tissue (which normally provides insulation), some people become more sensitive to cold temperatures. Additionally, semaglutide can affect the hypothalamus, the brain region that regulates body temperature. Some key points to consider:
- Semaglutide's effects on weight loss and metabolism may contribute to increased sensitivity to cold temperatures 1
- The hypothalamus, which regulates body temperature, can be affected by semaglutide 1
- While feeling cold is not a commonly reported side effect, it is essential to discuss any persistent or severe cold sensations with a healthcare provider, as it could potentially indicate other issues such as thyroid dysfunction 1 If you're experiencing persistent or severe cold sensations while taking semaglutide, it's crucial to discuss this with your healthcare provider, as it could potentially indicate other issues such as thyroid dysfunction. They may recommend monitoring your thyroid function or adjusting your medication dosage if necessary, as seen in the management of common adverse effects of GLP-1 receptor agonists 1. In the meantime, dressing in layers and keeping your environment at a comfortable temperature may help manage this symptom.
From the Research
Semaglutide and Feeling Cold
There is no direct evidence in the provided studies that suggests semaglutide can make you feel cold.
- The studies focus on the safety and efficacy of semaglutide in managing diabetes, obesity, and cardiovascular outcomes, as well as its potential benefits and risks 2, 3, 4, 5, 6.
- Adverse events associated with semaglutide, such as gastrointestinal side effects, pancreatic safety concerns, and injection-site reactions, are discussed in the studies 3, 5.
- However, none of the studies mention feeling cold as a potential side effect of semaglutide.
Potential Mechanisms
While the exact mechanisms of semaglutide are discussed in the studies, there is no indication that it would affect body temperature regulation or cause feelings of coldness 2, 3, 5.