What are the urgent differential diagnoses for a patient with epigastric burning pain radiating to the neck and associated shortness of breath?

Urgent Differential Diagnoses for Epigastric Burning Pain Radiating to Neck with Shortness of Breath

This presentation demands immediate exclusion of acute coronary syndrome before considering gastrointestinal causes, as myocardial infarction frequently presents with epigastric pain—particularly in women, diabetics, and elderly patients—and carries a 10–20% mortality if missed. 1, 2

Life-Threatening Causes (Rule Out First)

Acute Coronary Syndrome

• Obtain a 12-lead ECG within 10 minutes of presentation, as myocardial ischemia can manifest as epigastric burning, especially in atypical populations (women, diabetics, elderly). 1, 2
• Measure serial cardiac troponins at 0 and 6 hours—a single measurement is insufficient to exclude acute coronary syndrome. 1, 2
• The combination of epigastric pain with dyspnea (shortness of breath) is particularly worrisome, with more than twice the risk of death compared to typical angina, and increases sudden cardiac death risk 4-fold even without prior coronary disease. 1
• Radiation to the neck, jaw, or shoulder is a classic feature of cardiac ischemia, though the discomfort may be described as burning, pressure, or tightness rather than "pain." 1

Acute Aortic Dissection

• Sudden, severe epigastric pain radiating to the neck or back in patients over 50 years with vascular risk factors (hypertension, smoking) requires emergent imaging to exclude aortic dissection. 3, 4, 5
• Check for pulse differential between upper extremities and obtain urgent contrast-enhanced CT if clinical suspicion exists. 5, 6

Perforated Peptic Ulcer

• Sudden onset of severe epigastric pain that becomes generalized, accompanied by fever, abdominal rigidity, and absent bowel sounds suggests perforation. 3, 2
• Mortality reaches 30% if surgical intervention is delayed. 3, 2
• CT abdomen/pelvis with IV contrast shows extraluminal gas in 97% of cases, fluid or fat stranding in 89%, ascites in 89%, and focal wall defect in 84%. 3, 2

Acute Pulmonary Embolism

• Dyspnea disproportionate to chest discomfort, especially with tachypnea, should raise suspicion for pulmonary embolism. 7, 6
• Apply Wells criteria to stratify risk and consider urgent imaging. 6

Common Gastrointestinal Causes (After Cardiac Exclusion)

Gastroesophageal Reflux Disease (GERD)

• GERD affects 42% of Americans monthly and 7% daily, presenting with epigastric burning, heartburn, and regurgitation. 3, 2
• The burning sensation can radiate to the neck, jaw, or throat due to shared sensory innervation from the same spinal segments. 1, 7
• More than 50% of GERD patients have normal endoscopy (non-erosive reflux disease), so absence of esophagitis does not exclude the diagnosis. 3

Peptic Ulcer Disease

• Incidence of 0.1–0.3%, with complications occurring in 2–10% of cases. 3, 2
• Epigastric pain not relieved by antacids, potentially accompanied by nausea or hematemesis. 3
• H. pylori testing (^13^C-urea breath test or stool antigen—not serology) is mandatory for any patient with epigastric pain. 3

Acute Pancreatitis

• Epigastric pain radiating to the back, accompanied by nausea and vomiting. 3, 2
• Serum amylase ≥4× normal or lipase ≥2× normal has 80–90% sensitivity and specificity. 3, 2
• Overall mortality <10%, but reaches 30–40% in necrotizing pancreatitis. 3, 2

Esophageal Spasm

• Deep thoracic burning pain that may extend throughout the chest and neck, often confused with cardiac ischemia. 7, 8
• Pain may be relieved by nitroglycerin, further mimicking angina. 7

Immediate Diagnostic Algorithm

Step 1: Vital Signs & Physical Examination

• Check for hypotension, tachycardia ≥110 bpm, or fever ≥38°C, which predict perforation, shock, or sepsis with high specificity. 3, 2
• Assess for peritoneal signs (rigidity, rebound tenderness), cardiac murmurs, irregular pulse, jugular venous distension. 2
• Examine for epigastric tenderness, which suggests organic pathology rather than functional disease. 3

Step 2: Immediate Laboratory & Imaging

• ECG within 10 minutes to detect ST-segment changes, new left bundle branch block, Q waves, or T-wave inversions. 1, 2, 6
• Cardiac troponins at 0 and 6 hours—do not rely on a single measurement. 1, 4, 2
• Complete blood count (to detect anemia, an alarm feature requiring urgent endoscopy). 3
• Comprehensive metabolic panel, serum lactate, liver and renal function tests. 3, 2
• Serum amylase or lipase to exclude pancreatitis. 3, 2
• Contrast-enhanced CT abdomen/pelvis if diagnosis remains unclear after initial workup or if alarm features present (age ≥55 years, weight loss, anemia, vomiting, hematemesis). 3, 4, 2

Step 3: Risk Stratification for Cardiac vs. Non-Cardiac

• High-risk features requiring immediate cardiology consultation: ST-segment changes on ECG, elevated troponins, age >50 with new-onset symptoms, diabetes, hypertension, smoking history. 1, 4, 2
• If cardiac workup is negative and patient is stable: proceed with gastrointestinal evaluation (H. pylori testing, empiric PPI trial, consider endoscopy based on age and alarm features). 3

Initial Management (While Awaiting Diagnosis)

For All Patients

• Maintain NPO status until surgical emergency is excluded. 4, 2
• Establish IV access and provide fluid resuscitation if hemodynamically unstable. 4, 2
• Administer aspirin 162–325 mg (chewed) if acute coronary syndrome is suspected and no contraindications exist. 1
• Sublingual nitroglycerin may be given if cardiac ischemia is suspected; however, note that it can also relieve esophageal spasm, so response does not definitively distinguish cardiac from esophageal causes. 1, 7

For Suspected Gastrointestinal Pathology (After Cardiac Exclusion)

• Start high-dose PPI therapy (omeprazole 20–40 mg once daily before meals) immediately while awaiting diagnostic workup. 3, 2
• Full-dose PPI achieves 80–90% healing of duodenal ulcers and 70–80% healing of gastric ulcers. 3, 2
• Avoid NSAIDs, as they worsen peptic ulcer disease and increase bleeding risk. 3, 2

For Nausea/Vomiting

• Ondansetron 8 mg sublingual every 4–6 hours, promethazine 12.5–25 mg orally/rectally every 4–6 hours, or prochlorperazine 5–10 mg every 6–8 hours. 3
• Obtain baseline ECG before administering ondansetron due to QTc prolongation risk. 3

Critical Pitfalls to Avoid

• Never dismiss cardiac causes in patients with "atypical" epigastric pain, regardless of age or presentation—one-third of myocardial infarctions present without chest discomfort. 1, 4, 2
• Do not assume GERD without first excluding life-threatening causes, even in patients with known reflux disease. 4
• Persistent vomiting is a red-flag symptom that excludes functional dyspepsia and mandates investigation for structural disease (peptic ulcer, gastric outlet obstruction, malignancy). 3
• Delaying imaging in patients with peritoneal signs significantly increases mortality from perforated ulcer. 4, 2
• A single troponin measurement is insufficient—serial measurements at least 6 hours apart are required to exclude NSTEMI. 4, 2
• Dyspnea accompanying epigastric pain is a particularly ominous sign and should never be attributed to anxiety or reflux without thorough cardiac evaluation. 1

Indications for Urgent Endoscopy (Within 2 Weeks)

• Age ≥55 years with new-onset dyspeptic symptoms. 3
• Any alarm feature: unintentional weight loss, anemia on CBC, dysphagia, persistent vomiting, hematemesis, palpable epigastric mass. 3
• Epigastric tenderness on examination despite therapy. 3
• Symptoms persist beyond 4–8 weeks of PPI therapy. 3