From the Guidelines
Keflex (cephalexin) can be taken with or without food, but taking it with food may help reduce stomach upset. The dosage of Keflex is typically 20 mg per kg per dose twice daily, with a maximum of 500 mg per dose, for 10 days 1. It is essential to complete the entire prescribed course of antibiotics, even if symptoms improve before finishing the treatment. Each dose should be taken with a full glass of water. While taking antibiotics with food may slow their absorption slightly, it does not significantly affect the overall effectiveness of Keflex. Consistent timing between doses is crucial to maintain a steady level of the antibiotic in the bloodstream. If a dose is missed, it should be taken as soon as possible, unless it's almost time for the next dose, in which case the missed dose should be skipped and the regular schedule continued.
Some key points to consider when taking Keflex include:
- Taking the medication with food if stomach upset occurs
- Completing the full course of treatment as prescribed
- Taking each dose with a full glass of water
- Maintaining consistent timing between doses
- Skipping a missed dose if it's almost time for the next one
It's also important to note that Keflex is effective against certain bacterial infections, and its use should be guided by the severity of the infection and the patient's medical history, including any allergies to penicillin 1. However, the provided evidence does not directly address the issue of taking Keflex with food in relation to its effectiveness or absorption, but it does provide guidance on the dosage and duration of treatment 1.
From the FDA Drug Label
Cephalexin is acid stable and may be given without regard to meals. The answer is no, you do not have to take Keflex with food, as it can be given without regard to meals 2.
From the Research
Administration of Keflex with Food
- There is no direct evidence in the provided studies that suggests Keflex (cephalexin) must be taken with food.
- However, study 3 discusses the pharmacokinetics of cephalexin, including its absorption and bioavailability, but does not specifically address the need to take it with food.
- Study 4 mentions that over-the-counter NSAIDs should be taken on a fasting stomach, not with food, but this does not apply to antibiotics like Keflex.
- Studies 5, 6, and 7 do not provide information on whether Keflex should be taken with food.
- It is essential to follow the specific instructions provided by the healthcare provider or the medication label for the correct administration of Keflex.