From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
Ademetionine (SAMe) can be taken for a duration of 4-6 weeks for depression, 2-4 weeks initially for liver conditions, and 4-12 weeks for osteoarthritis, with the possibility of continuation under medical supervision. The treatment duration and dosage of ademetionine vary based on the condition being treated. For depression, the most recent and highest quality study 1 suggests that ademetionine is effective in treating major depressive disorder, with a recommended treatment duration of 4-6 weeks to evaluate effectiveness. The typical dosage ranges from 400-1600 mg daily, often divided into multiple doses. Ademetionine works by supporting methylation reactions in the body, helping to produce and regulate hormones, neurotransmitters, and maintaining cell membranes. It also supports glutathione production, which helps detoxify the liver. Some key points to consider when taking ademetionine include:
- Side effects may include nausea, diarrhea, headache, and anxiety
- Patients with bipolar disorder should avoid ademetionine as it may trigger manic episodes
- Always consult with a healthcare provider before starting, stopping, or adjusting the duration of ademetionine treatment, as individual needs vary based on medical history and response to treatment
- The safety and efficacy of ademetionine have been established in various studies, including a systematic review and meta-analysis 2 that showed its effectiveness in improving liver function. However, it is essential to prioritize the most recent and highest quality study, which in this case is 1, to guide treatment decisions.