From the Research
Lion's mane mushroom shows limited effectiveness for cognitive and neurological benefits, and its use should be approached with caution due to the lack of rigorous human clinical trials establishing its efficacy for specific conditions. The current evidence suggests that lion's mane may support nerve growth, improve mild cognitive impairment, reduce anxiety and depression symptoms, and potentially aid in recovery from nervous system injuries 1. However, the majority of studies have methodological limitations, and more research is needed to fully establish its effectiveness.
Some studies have investigated the effects of lion's mane on cognitive function, stress, and mood in healthy adults. For example, a 2023 pilot study found that lion's mane supplementation may improve speed of performance and reduce subjective stress in healthy, young adults 1. Another study published in 2022 found no significant effects of lion's mane on markers of metabolic flexibility or cognition in a college-age cohort 2.
The typical dosage of lion's mane extract ranges from 500-3000mg daily, with many users taking 1000mg daily divided into two doses. It is recommended to look for products standardized to contain at least 30% beta-glucans, the active compounds believed responsible for its benefits. Lion's mane appears to work by stimulating nerve growth factor (NGF) production, which supports neuron health and function.
While lion's mane is generally considered safe with minimal side effects, results vary between individuals, and it may take 2-4 weeks of consistent use to become noticeable. The research is still emerging, and more rigorous human clinical trials are needed to fully establish its effectiveness for specific conditions. As noted in a 2024 study, there is currently not enough information to support the use of lion's mane for treating amyotrophic lateral sclerosis (ALS), and further research is needed to study its efficacy 3.
Key points to consider:
- Lion's mane may have limited effectiveness for cognitive and neurological benefits
- More rigorous human clinical trials are needed to establish its efficacy for specific conditions
- Typical dosage ranges from 500-3000mg daily of extract
- Look for products standardized to contain at least 30% beta-glucans
- Lion's mane appears to work by stimulating nerve growth factor (NGF) production
- Generally considered safe with minimal side effects, but results vary between individuals.