Retatrutide Concentration Calculation
36 mg of Retatrutide diluted in 180 mL of normal saline yields a concentration of 0.2 mg/mL.
Mathematical Calculation
The concentration is calculated using the basic formula: concentration = total drug amount ÷ total volume.
Calculation: 36 mg ÷ 180 mL = 0.2 mg/mL
This represents a straightforward dilution where the drug mass is distributed evenly throughout the diluent volume.
Clinical Context for Retatrutide
While the provided evidence does not contain specific guidelines for preparing Retatrutide dilutions at this concentration, the clinical trial data provides context for typical dosing:
Retatrutide is administered as a subcutaneous injection once weekly in clinical trials, with doses ranging from 1 mg to 12 mg 1, 2.
In phase 2 trials for obesity, participants received subcutaneous doses of 1 mg, 4 mg, 8 mg, or 12 mg weekly, with dose escalation strategies starting at 2 mg or 4 mg for higher maintenance doses 1.
For type 2 diabetes, the studied dose range was 0.5 mg to 12 mg administered subcutaneously once weekly 2.
Important Safety Considerations
The most common adverse events with Retatrutide are gastrointestinal (nausea, diarrhea, vomiting, constipation), which are dose-related and mostly mild to moderate in severity 1, 2.
Dose-dependent increases in heart rate have been observed, peaking at 24 weeks and declining thereafter, with increases up to 6.7 beats/min 1, 3.
The preparation you describe (36 mg in 180 mL) is not a standard concentration reported in clinical trials and may represent a compounding or research protocol rather than standard clinical administration 1, 2.