What is the best treatment for sore throat and fatigue in infectious mononucleosis?

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Treatment of Sore Throat and Fatigue in Infectious Mononucleosis

The best treatment for infectious mononucleosis is supportive care with ibuprofen or paracetamol for symptom relief, activity restriction for 8 weeks to prevent splenic rupture, and avoidance of corticosteroids in uncomplicated cases. 1, 2

Symptomatic Management

  • Use ibuprofen or paracetamol as first-line analgesics for sore throat pain, with ibuprofen showing slightly better efficacy for pain relief 3
  • Both medications are safe for short-term use and should be dosed according to standard directions 4, 3
  • Ensure adequate hydration and allow the patient's energy level to guide activity—do not enforce strict bed rest 2
  • Fatigue typically resolves within 3 months, though it may persist longer in some patients 1, 2

Activity Restriction to Prevent Splenic Rupture

  • Patients must avoid contact sports and strenuous exercise for 8 weeks from symptom onset or until splenomegaly resolves, whichever is longer 1
  • Splenic rupture occurs in 0.1-0.5% of infectious mononucleosis cases and is the most feared, potentially life-threatening complication 1
  • Splenomegaly occurs in approximately 50% of cases, making this restriction critical for all patients 1

What NOT to Use

  • Do not use corticosteroids for routine treatment of uncomplicated infectious mononucleosis 2
  • Corticosteroids are only indicated for respiratory compromise or severe pharyngeal edema causing airway obstruction 2, 5
  • Prolonged steroid use in uncomplicated cases has been associated with severe complications including septic shock, polymicrobial bacteremia, and septic emboli 6
  • Acyclovir and antihistamines are not recommended for routine treatment 2

When to Consider Corticosteroids (Rare Indications Only)

  • Reserve corticosteroids exclusively for patients with impending airway obstruction from severe pharyngeal edema 2, 5
  • Consider corticosteroids for hematological complications (severe thrombocytopenia or hemolytic anemia) 6, 5
  • Use single low-dose oral dexamethasone (maximum 10 mg) if corticosteroids are indicated 3

Key Clinical Pitfalls

  • Never prescribe antibiotics for infectious mononucleosis—the condition is viral and antibiotics provide no benefit 1, 7
  • Avoid amoxicillin/ampicillin specifically, as these cause a characteristic rash in 90% of infectious mononucleosis patients 1
  • Do not use the Centor criteria to guide antibiotic decisions in infectious mononucleosis—these criteria are designed for bacterial pharyngitis, not viral infections 4, 8
  • Most patients recover uneventfully within 2-3 weeks, though fatigue and need for sleep may persist for several months 2, 5

References

Research

Infectious Mononucleosis: An Updated Review.

Current pediatric reviews, 2024

Research

Epstein-Barr virus infectious mononucleosis.

American family physician, 2004

Guideline

Management of Acute Pharyngitis

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Treatment of Sore Throat in Adults with Renal Impairment

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

[Infectious mononucleosis--a "childhood disease" of great medical concern].

Medizinische Monatsschrift fur Pharmazeuten, 2013

Guideline

Management of Severe Sore Throat

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2026

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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