Does Vyvanse (lisdexamfetamine) or Prozac (fluoxetine) cause tinnitus?

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Last updated: April 25, 2025View editorial policy

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From the Guidelines

Both Vyvanse and Prozac can potentially cause tinnitus, but the evidence provided does not directly support this claim, and the risk appears to be low based on the available data 1. When considering the potential for tinnitus as a side effect of Vyvanse or Prozac, it's essential to weigh the benefits of these medications against their potential risks.

  • The provided evidence primarily discusses the use of selective serotonin reuptake inhibitors (SSRIs) like Prozac for premature ejaculation and their side effects in this context 1.
  • While the evidence does mention various side effects associated with SSRIs, such as nausea, dry mouth, drowsiness, and reduced libido, it does not specifically address tinnitus as a common side effect 1.
  • Given the lack of direct evidence linking Vyvanse or Prozac to tinnitus in the provided studies, the decision to use these medications should be based on their established benefits and potential side effects, with careful monitoring for any adverse effects, including tinnitus.
  • If tinnitus occurs, healthcare providers may consider adjusting the dosage or switching to an alternative medication, emphasizing the importance of medical supervision when managing medications like Vyvanse and Prozac 1.

From the Research

Tinnitus and Vyvanse or Prozac

  • There are no direct studies in the provided evidence that investigate the relationship between Vyvanse (lisdexamfetamine) or Prozac (fluoxetine) and tinnitus.
  • The studies provided focus on the efficacy, safety, and tolerability of lisdexamfetamine in the treatment of attention-deficit hyperactivity disorder (ADHD) 2, 3, 4, binge eating disorder 3, and methamphetamine use disorder 5, as well as its use as an antidepressant augmentation strategy 6.
  • None of the studies mention tinnitus as a potential side effect or outcome of treatment with lisdexamfetamine or any other medication.
  • Prozac (fluoxetine) is not mentioned in any of the provided studies.
  • Therefore, there is no evidence from the provided studies to suggest that Vyvanse or Prozac causes tinnitus 2, 3, 5, 6, 4.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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