What is the difference between Hyaluronic Acid (HA) 70 and Profhilo (High Concentration Hyaluronic Acid)

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Last updated: April 25, 2025View editorial policy

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From the Research

The main difference between 70 Hyal and Profhilo lies in their composition, intended use, and mechanism of action, with Profhilo being a more recent and innovative approach to skin rejuvenation, as supported by the latest study from 2022 1. The composition of 70 Hyal typically refers to a hyaluronic acid filler with a 70% concentration, designed primarily for adding volume and contouring specific facial areas. On the other hand, Profhilo is a specific brand of injectable hyaluronic acid that contains a unique formulation of high and low molecular weight hyaluronic acid (32mg/ml) without any cross-linking agents. Some key points to consider are:

  • Profhilo functions as a "bio-remodeling" treatment rather than a traditional filler, spreading beneath the skin after injection to stimulate collagen and elastin production, thereby improving skin quality, hydration, and elasticity across broader facial areas 1.
  • The effects of Profhilo typically last about six months, while traditional fillers like 70 Hyal may last 6-18 months depending on the specific product and area treated 1.
  • Recent studies have shown that hyaluronic acid plays a crucial role in skin hydration, elasticity, and firmness, making it an essential component in various cosmetic and dermatological treatments 2.
  • The latest research from 2025 highlights the importance of hyaluronic acid in skin aging and wound healing, with its applications extending to anti-aging formulations, nutricosmetics, and skin biostimulators 2. In terms of recommendation, based on the most recent and highest quality study from 2022, Profhilo is preferred over 70 Hyal for its innovative bio-remodeling approach and ability to stimulate collagen and elastin production, leading to improved skin quality and hydration 1.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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