From the Guidelines
Splenic rupture is a rare adverse event associated with Calquence (acalabrutinib). However, the provided evidence does not directly address the risk of splenic rupture associated with Calquence (acalabrutinib) [ 1 ].
- The evidence discusses splenic abscess and infarction in the context of infective endocarditis, which is a different condition [ 1 ].
- It highlights the importance of monitoring for signs and symptoms of splenic complications, such as abdominal pain and tenderness, in patients with certain medical conditions [ 1 ].
- Although the evidence does not provide specific information on the risk of splenic rupture associated with Calquence (acalabrutinib), it is essential to monitor patients receiving this medication for any signs of splenic complications.
- Prompt medical attention should be sought if splenic rupture is suspected, as it can be a life-threatening condition.
- The evidence suggests that imaging studies, such as abdominal CT and MRI, can be useful in diagnosing splenic complications [ 1 ].
From the Research
Risk of Splenic Rupture
The risk of splenic rupture associated with Calquence (acalabrutinib) is not directly addressed in the provided studies. However, the studies discuss the risk of splenic rupture in various contexts:
- Spontaneous splenic rupture is a rare and life-threatening condition that can occur in patients with underlying pathological conditions, such as hematologic malignancies 2, 3.
- Atraumatic idiopathic splenic rupture can be induced by granulocyte-colony stimulating factor (G-CSF) administration 4.
- Splenic rupture can occur in patients with infectious mononucleosis, although this is a rare complication 5.
- Delayed splenic rupture is a rare complication of non-operative management of primary splenic trauma, and can occur months after the initial injury 6.
Key Points
- The provided studies do not specifically mention Calquence (acalabrutinib) as a risk factor for splenic rupture.
- Splenic rupture is a potentially life-threatening condition that requires prompt diagnosis and treatment.
- The risk of splenic rupture is associated with various underlying conditions, including hematologic malignancies, G-CSF administration, and infectious mononucleosis.
- Delayed splenic rupture is a rare complication of non-operative management of primary splenic trauma.
Symptoms and Diagnosis
- The most common symptom of spontaneous splenic rupture is acute abdominal pain, which can radiate to the left shoulder 2, 5.
- Diagnostic methods of choice for splenic rupture include computed tomography and ultrasound 2, 3.
- Laboratory results may indicate low hemoglobin and hematocrit levels, as well as other abnormalities 5.