What is the summarized screening test in a patient with Diabetes Mellitus (DM)?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: April 27, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Guidelines

Patients with diabetes should undergo annual comprehensive eye exams, annual urine tests for microalbuminuria, and regular monitoring of blood glucose levels and hemoglobin A1C every 3-6 months to detect and manage complications early. When it comes to screening tests for patients with diabetes, several key areas need to be addressed to prevent morbidity, mortality, and to improve quality of life.

  • Annual comprehensive eye exams by an ophthalmologist or optometrist should begin for patients who have had T1DM for more than 5 years and for those with T2DM at diagnosis 1.
  • Annual urine tests for microalbuminuria via urine albumin–creatinine ratio on a spot urine sample and eGFR should be performed in patients who have had T1DM for at least 5 years, in all patients with T2DM, and in all patients with comorbid hypertension 1.
  • Regular monitoring of blood glucose levels and hemoglobin A1C every 3-6 months is crucial for maintaining optimal glycemic control and reducing the risk of microvascular and macrovascular complications 1. Additionally, patients with diabetes should undergo regular foot examinations to check for neuropathy and vascular complications, and blood pressure should be measured at every routine visit, with a target of less than 140/90 mmHg for most patients. A fasting lipid profile should be obtained at diagnosis and then annually, with LDL targets typically below 100 mg/dL. These screening tests are essential because diabetes affects multiple organ systems, and early detection of complications allows for timely intervention to prevent disease progression, ultimately improving quality of life and reducing mortality in patients with diabetes 1.

From the Research

Screening Tests for Patients with Diabetes

  • Eye exams are an important screening tool for patients with diabetes to prevent severe and vision-threatening complications such as cataracts, glaucoma, and retinopathy 2
  • Early detection and treatment of diabetic retinopathy can result in a significant decrease in vision loss 2
  • Screening for diabetic nephropathy is also crucial, as it can lead to end-stage renal disease and increased mortality 3, 4

Recommended Screening Guidelines

  • Fasting plasma glucose of 100 mg/dl or greater, random plasma glucose of 130 mg/dl or greater, or HbA1c greater than 6.0% should prompt further testing and closer follow-up 5
  • HbA1c of 6.5-6.9% or greater, confirmed by a plasma glucose-specific test, should establish the diagnosis of diabetes 5
  • HbA1c of 7% or greater, confirmed by another HbA1c- or a plasma glucose-specific test, should establish the diagnosis of diabetes 5

Importance of Early Detection and Treatment

  • Early detection and treatment of diabetic complications can improve patient outcomes and reduce morbidity and mortality 2, 3, 4
  • Metformin therapy has been shown to be effective and safe in patients with diabetic nephropathy, compared to sulfonylureas 6

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Screening recommendations for diabetics.

Disease-a-month : DM, 2021

Research

Diabetic nephropathy and retinopathy.

The Medical clinics of North America, 2004

Research

A new look at screening and diagnosing diabetes mellitus.

The Journal of clinical endocrinology and metabolism, 2008

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.