From the Guidelines
The correct dose for NAD+ supplementation is not explicitly stated in the provided guidelines, but based on the information about nicotinamide, a dose of approximately 900 mg/d for adults can be considered safe, as it is the upper intake level (UL) set for nicotinamide 1. When considering NAD+ supplementation, it's essential to understand that NAD+ is a coenzyme formed from niacin, and its supplementation aims to support cellular energy production, DNA repair, and other metabolic functions.
- The body's NAD+ levels naturally decline with age, and supplementation may help restore these levels.
- Niacin, a precursor to NAD+, is obtained in the diet from various whole and processed foods, with the highest contents in fortified packaged foods, meat, poultry, and certain fish, and can also be synthesized from the amino acid tryptophan in the liver 1.
- It's crucial to consult with a healthcare provider before starting NAD+ supplementation, especially if you have existing health conditions or take medications, as individual responses to supplementation may vary.
- The provided guidelines do not specify the optimal dose for NAD+ supplementation directly, but they do offer insight into the safety and functions of niacin and its metabolically active form, NAD+, which can inform decisions about supplementation 1.
From the Research
NAD+ Supplementation Dosing
The correct dose for NAD+ supplementation is not explicitly stated in the provided studies. However, the following points can be considered:
- The studies suggest that NAD+ precursors such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) can increase NAD+ levels in the body 2, 3, 4, 5, 6.
- The dosing regimens and study durations vary greatly across interventions, and small sample sizes limit data interpretation of physiological outcomes 2.
- NR and NMN have been found to be safe and tolerable, and can increase the abundance of NAD+ and related metabolites in multiple tissues 2, 4, 6.
- The biochemistry and metabolism of NAD+ precursors, as well as their beneficial physiological effects, are still being researched 3, 4, 5, 6.
Key Findings
- Nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are the most common NAD+ precursors studied for their potential to improve physiological function in humans 2, 6.
- Reduced nicotinamide mononucleotide (NMNH) has been identified as a new and potent NAD+ precursor, with potential therapeutic applications 5.
- NAD+ precursors may have beneficial effects on various diseases, including diabetes, Alzheimer's disease, endothelial dysfunction, and inflammation 4, 6.