From the FDA Drug Label
ADVERSE REACTIONS ... Cardiovascular:Hypotension (0% to 9%). Rare instances of dyspnea, palpitation, chest pain, syncope. Yes, baclofen can affect blood pressure, as it may cause hypotension in some patients 1.
From the Research
Baclofen can affect blood pressure, and its use may lead to hypotension in some patients. This muscle relaxant medication, commonly prescribed for muscle spasticity, acts on GABA-B receptors in the central nervous system, which can influence autonomic functions including cardiovascular regulation 2. Typical oral dosing of baclofen starts at 5 mg three times daily, gradually increasing to an optimal dose that may range from 40-80 mg daily divided into multiple doses. Patients taking baclofen should monitor their blood pressure, especially when starting treatment or increasing doses.
Some key points to consider:
- Baclofen's effect on blood pressure is due to its action on GABA-B receptors, which can influence autonomic functions including cardiovascular regulation 3.
- People with hypertension or cardiovascular conditions should inform their healthcare provider before taking baclofen, as they may be more susceptible to the blood pressure-lowering effects of the medication 4.
- Some patients may experience dizziness or lightheadedness when standing up quickly due to orthostatic hypotension, and if significant blood pressure changes occur while taking baclofen, patients should contact their healthcare provider rather than discontinuing the medication abruptly 5.
- The most recent and highest quality study on blood pressure management, published in 2021, suggests that pharmacological blood pressure lowering can reduce the risk of major cardiovascular events by about 10%, irrespective of previous diagnoses of cardiovascular disease, and even at normal or high-normal blood pressure values 5.
Overall, while baclofen can affect blood pressure, its use should be carefully monitored, especially in patients with pre-existing hypertension or cardiovascular conditions. Healthcare providers should emphasize the importance of blood pressure monitoring and adjust treatment regimens as needed to minimize the risk of adverse effects.