From the Research
Yes, there are studies suggesting a negative correlation between high ferritin serum levels and longevity, with elevated ferritin levels associated with increased mortality risk and reduced lifespan, as seen in a study published in 2021 1. Elevated ferritin levels, particularly above 200 ng/mL in men and 150 ng/mL in women, have been associated with increased mortality risk and reduced lifespan. This relationship appears to be due to iron's oxidative properties, as excess iron can generate harmful free radicals that damage cells and tissues throughout the body. High ferritin has been linked to increased risks of:
- Cardiovascular disease
- Diabetes
- Neurodegenerative disorders
- Certain cancers - all conditions that can reduce longevity. The body lacks an efficient mechanism to excrete excess iron, making it important to monitor and manage ferritin levels. For those with elevated ferritin, therapeutic phlebotomy (blood donation) is often recommended as a simple intervention, typically removing 500mL of blood every 2-3 months until ferritin levels normalize, as supported by a study published in 2020 2. Dietary modifications such as reducing red meat consumption, avoiding iron supplements unless prescribed, and limiting vitamin C with iron-rich meals can also help manage iron levels. Regular monitoring of ferritin levels is advisable, especially for those with a family history of hemochromatosis or other iron overload disorders, as highlighted in a study published in 2021 3. It is essential to note that ferritin levels can be influenced by inflammation, and therefore, should be considered in conjunction with other markers, such as CRP levels, as mentioned in a study published in 2013 4. Overall, managing ferritin levels is crucial to reducing the risk of iron overload-related diseases and improving overall health and longevity.