What is the diagnosis for a 4-year-old child presenting with intermittent high fever for 5 days, accompanied by rhinorrhea (runny nose) and a mild cough, who remains hydrated, has normal urine output, but exhibits lethargy and normal respiratory rate?

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Last updated: April 28, 2025View editorial policy

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Differential Diagnosis for a 4-year-old child with 5 days of high fever, runny nose, mild cough, lethargy, and normal breathing

  • Single most likely diagnosis:
    • Viral upper respiratory tract infection (URTI) - The symptoms of high fever, runny nose, and mild cough, which have been present for 5 days and have waxed and waned, are consistent with a viral URTI. The child's ability to hold fluids and urinate properly suggests that they are not severely dehydrated, which is common in viral infections.
  • Other Likely diagnoses:
    • Influenza - Given the symptoms of high fever, runny nose, and mild cough, influenza is a possible diagnosis, especially during flu season. The lethargy could be due to the infection itself.
    • Pharyngitis - Although not explicitly mentioned, the symptoms could also suggest pharyngitis, especially if the child has a sore throat, which is not uncommon with viral infections.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.):
    • Bacterial meningitis - Although the child is breathing normally and can hold fluids, bacterial meningitis can present with non-specific symptoms such as fever and lethargy. It is crucial to consider this diagnosis due to its high morbidity and mortality if not treated promptly.
    • Sepsis - Any child with a high fever and lethargy should be evaluated for sepsis, as it can be life-threatening. The fact that the child can hold fluids and is peeing properly is a good sign, but sepsis can progress rapidly.
    • Pneumonia - Although the child is breathing normally, pneumonia should be considered, especially if the cough worsens or if there are signs of respiratory distress. Some pneumonias can present with minimal respiratory symptoms initially.
  • Rare diagnoses:
    • Kawasaki disease - This condition can present with fever, lethargy, and sometimes respiratory symptoms. It's more common in children under 5 and requires prompt diagnosis to prevent cardiac complications.
    • Leukemia - Although rare, leukemia can present with non-specific symptoms such as fever, lethargy, and sometimes respiratory infections due to immunosuppression. It's essential to consider in the differential diagnosis of a child with persistent or recurrent infections.

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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