From the Research
For a 10-year-old boy, the recommended dose of meclizine for motion sickness is 12.5 to 25 mg taken 1 hour before travel, with the dose repeated every 12-24 hours as needed during the journey. This recommendation is based on the most recent and highest quality study available, which evaluated the safety and pharmacokinetics of meclizine in children with achondroplasia 1. The study found that meclizine 12.5 and 25 mg/day was safe and well-tolerated in children aged 5-10 years.
Key Considerations
- Meclizine is an antihistamine that works by blocking certain receptors in the brain that trigger nausea and vomiting associated with motion sickness.
- The medication should not be used for more than a few days without medical supervision.
- Parents should consult with their child's pediatrician before administering meclizine, as the doctor may recommend alternative medications specifically approved for children this age.
- Side effects may include drowsiness, dry mouth, and blurred vision, so activities requiring alertness should be avoided.
- The medication should be given with or without food, and the child should have access to water to prevent dry mouth.
Evidence Summary
The study by 1 provides the most recent and relevant evidence for the use of meclizine in children. The study found that meclizine 12.5 and 25 mg/day was safe and well-tolerated in children aged 5-10 years, with no serious adverse events reported. The pharmacokinetic parameters of meclizine were also evaluated, and the results showed that the plasma concentration of meclizine achieved a steady state after 14 days of repeated administration.
Clinical Implications
The recommended dose of meclizine for motion sickness in a 10-year-old boy is 12.5 to 25 mg taken 1 hour before travel, with the dose repeated every 12-24 hours as needed during the journey. It is essential to monitor the child for any adverse effects and to consult with a pediatrician if any concerns arise. Additionally, meclizine should not be used for more than a few days without medical supervision, and alternative medications may be recommended for children under 12 years of age.