What are the treatment options for depersonalization disorder?

Treatment for depersonalization disorder typically involves a combination of psychotherapy and medication. Cognitive-behavioral therapy (CBT) is considered the first-line treatment, helping patients identify and change negative thought patterns that contribute to depersonalization symptoms. Mindfulness techniques and grounding exercises are particularly effective, teaching patients to reconnect with their physical sensations and present moment. Medications may include SSRIs like sertraline (50-200mg daily) or fluoxetine (20-80mg daily), which can help manage associated anxiety and depression. Lamotrigine (starting at 25mg daily, gradually increasing to 100-200mg) has shown promise in some cases. Benzodiazepines like clonazepam (0.5-2mg daily) may provide short-term relief but should be used cautiously due to dependency risks. Therapy typically requires at least 12-16 weekly sessions, with some patients needing longer treatment. Addressing underlying trauma is crucial, as depersonalization often stems from past traumatic experiences. Lifestyle modifications including regular exercise, adequate sleep, stress management, and avoiding substances like cannabis and hallucinogens that can trigger symptoms are important complementary approaches. Recovery is possible but often gradual, with patients learning to manage symptoms rather than experiencing complete elimination.