From the Research
Zepbound may potentially worsen venous insufficiency in some patients due to its gastrointestinal side effects, particularly dehydration, which can exacerbate symptoms of venous insufficiency. The concern arises because Zepbound commonly causes nausea and vomiting, leading to dehydration, which can reduce blood volume and make blood thicker and more prone to pooling in the legs 1, 2, 3, 4, 5.
Key Considerations
- Dehydration can worsen symptoms of venous insufficiency by reducing blood volume and increasing blood viscosity.
- Rapid weight loss caused by Zepbound can temporarily worsen the appearance of varicose veins as the supporting fat tissue diminishes.
- Patients with pre-existing venous insufficiency should stay well-hydrated while taking Zepbound, consider wearing compression stockings, elevate their legs when possible, and maintain regular physical activity.
Management Strategies
- Staying well-hydrated to prevent dehydration and reduce the risk of worsening venous insufficiency symptoms.
- Wearing compression stockings to improve venous function and reduce swelling, as recommended by studies such as 2 and 5.
- Elevating the legs when possible to reduce swelling and improve venous return.
- Maintaining regular physical activity to improve circulation and reduce the risk of worsening venous insufficiency symptoms. It's essential to discuss any worsening of venous symptoms with a healthcare provider, who may need to adjust treatment for both conditions accordingly, considering the latest evidence on compression stockings and venous insufficiency management 2, 3, 5.