From the Guidelines
The standard treatment for colon cancer includes surgery, chemotherapy, radiation therapy, targeted therapy, and immunotherapy, with the choice of treatment depending on the stage of cancer. The term "snello" is not a recognized medical term or treatment for colon cancer. According to the most recent and highest quality study 1, the typical chemotherapy regimen for stage III colon cancer is FOLFOX given every two weeks for 12 cycles (about 6 months total), which has been shown to improve overall survival.
Key Considerations
- The primary treatment option for patients with stage III colon cancer is resection with curative intent, followed by adjuvant chemotherapy to improve overall survival 1.
- Oxaliplatin-based combination chemotherapy is the standard of care for stage III colon cancer, based on the results of studies such as the Adjuvant Treatment of Colon Cancer (MOSAIC) phase III randomized trial 1.
- The duration of oxaliplatin-containing adjuvant therapy for stage III colon cancer should be individualized, taking into account the risk of recurrence and the potential for peripheral sensory neurotoxicity 1.
Prevention Strategies
- Regular screening colonoscopies starting at age 45 for average-risk individuals can help reduce colon cancer risk by detecting and removing precancerous polyps 1.
- Maintaining a healthy weight, exercising regularly, limiting red meat consumption, avoiding processed meats, not smoking, limiting alcohol intake, and consuming a diet rich in fruits, vegetables, and whole grains can also help reduce colon cancer risk by minimizing exposure to carcinogens and promoting gut health 1.
From the FDA Drug Label
Oxaliplatin Injection, in combination with infusional fluorouracil and leucovorin, is indicated for: adjuvant treatment of stage III colon cancer in patients who have undergone complete resection of the primary tumor. treatment of advanced colorectal cancer.
The answer is: Oxaliplatin is used to treat colon cancer.
- Specifically, it is used for:
- Adjuvant treatment of stage III colon cancer
- Treatment of advanced colorectal cancer 2
From the Research
Treatment Options for Colon Cancer
- The treatment of metastatic colorectal cancer has improved with the availability of active cytotoxic drugs and biological agents, leading to a median overall survival of almost 2 years 3.
- Chemotherapy remains the primary option for patients with metastatic colorectal cancer, with the development of first-line chemotherapy regimens associated with higher activity and improved efficacy being a major topic of interest 3.
- The use of irinotecan, oxaliplatin, and 5-fluorouracil (5-FU) in combination has been shown to be effective in treating metastatic colorectal cancer, with a high response rate and improved overall survival 4.
Surgical Management of Colon Cancer
- Surgical resection of metastases can be a potentially curative approach for patients with metastases confined to the liver 5.
- For initially unresectable lesions, treatment regimens with high response rates may produce sufficient tumor shrinkage to permit complete resection 5.
- The management of the primary tumor has become increasingly complex, with a reasonable approach being to manage the primary tumor non-operatively in select cases of extracolonic disease requiring management 6.
Adjuvant Chemotherapy for Stage II and III Colon Cancer
- Patients with completely resected stage III colon cancer have an overall survival benefit from adjuvant chemotherapy, with combination chemotherapy providing a larger benefit than monotherapy 7.
- For stage II colon cancer, a clear overall survival benefit from adjuvant chemotherapy has not been shown, although patients with high-risk stage II disease may benefit from adjuvant chemotherapy 7.
- Patients younger than 70 years of age may derive greater disease-free survival and overall survival benefit from adjuvant chemotherapy compared with those older than 70 years 7.